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Comparative study of antibiofilm activity and physicochemical properties of microelectrode arrays

机译：微电极阵列抗血栓活性和物理化学特性的对比研究

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摘要

In this paper, the antibiofilm activity of microelectrode arrays (MEAs) related to their physicochemical properties was studied. Our objective was to determine whether any of the MEAs in contact with the biofilms elicit a considerable antibiofilm activity. Our hypothesis was that the antibiofilm activity of the MEAs depended on the materials used for the preparation of their tips. The antibiofilm activity of the samples was determined by measuring the ratio of the killed to alive bacteria incubated with microelectrodes. To our knowledge, the antibiofilm activity of MEAs related to their physicochemical properties has not been reported, yet. The use of different tips made of carbon nanotube (CNT) or platinum (Pt) for the samples allowed in situ monitoring of their antibiofilm activity. The complementary data of FTIR and SEM analysis of the samples before and after incubation with the biofilm revealed the attachment of proteins from biofilm on the sample tips. The confocal microscopy showed that the ratio of dead to alive cells incubated with the MEAs coated with parylene-C, the samples with Pt tips and the ones with CNT tips was 15.2% +/- 9.8%, 40.4% +/- 12.3% and 25.8% +/- 8.2%, respectively. This study presented the evidence of the effect of type of sample tips on the anti-biofilm effect of MEAs. These results suggest that MEAs with Pt tips, killing more bacteria than the ones with CNT tips or without coated tips, could be used for the preparation of sterile surfaces of these implants.
机译：本文研究了与其物理化学性质相关的微电极阵列（MEAS）的抗生素活性。我们的目的是确定与生物膜接触的任何测量是否引发了相当大的抗生素活性。我们的假设是测量的抗生素活性依赖于用于制备其提示的材料。通过测量与微电极孵育的杀死与活细菌的比例测定样品的抗血丝活性。据我们所知，尚未报道与其物理化学特性相关的MES的抗生素活性。使用由碳纳米管（CNT）或铂（Pt）制成的不同尖端，用于原位监测其抗生素活性的样品。与生物膜孵育之前和孵育前后样品的FTIR和SEM分析的互补数据显示蛋白质与生物膜的附着在样品尖端上。共聚焦显微镜表明，死于与聚对聚苯乙烯-C的测定的测定的活性细胞的比例，具有Pt提示的样品和CNT提示的样品为15.2％+/- 9.8％，40.4％+/- 12.3％和分别为25.8％+/- 8.2％。本研究提出了样品提示类型对测量抗生物膜效应的影响的证据。这些结果表明，用PT尖端的测量值，杀死比具有CNT尖端或没有涂层的尖端的细菌，可用于制备这些植入物的无菌表面。

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  • 来源
    《Microelectronic Engineering》 |2020年第5期|111305.1-111305.9|共9页
  • 作者

    Javanbakht Taraneh; Ghane-Motlagh Bahareh; Sawan Mohamad;

  • 作者单位

    Univ Montreal Dept Chem Montreal PQ H3C 3J7 Canada;

    Polytech Montreal Polyst Neurotechnol Lab Dept Elect Engn Montreal PQ H3C 3A7 Canada;

    Polytech Montreal Polyst Neurotechnol Lab Dept Elect Engn Montreal PQ H3C 3A7 Canada|Westlake Univ Sch Engn CenBRAIN Hangzhou 310024 Zhejiang Peoples R China|Westlake Inst Adv Study Inst Adv Study Hangzhou 310024 Zhejiang Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microelectrode arrays; Bacterial biofilm; FTIR; SEM; Fluorescence confocal microscopy;

    机译：微电极阵列;细菌生物膜;FTIR;SEM;荧光共聚焦显微镜;

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