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首页> 外文期刊>Microfluidics and nanofluidics >Microfluidic applications of functionalized magnetic particles for environmental analysis: focus on waterborne pathogen detection
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Microfluidic applications of functionalized magnetic particles for environmental analysis: focus on waterborne pathogen detection

机译：功能化磁性颗粒在环境分析中的微流体应用：专注于水生病原体检测

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The continuous surveillance of drinking water is extremely important to provide early warning of contamination and to ensure continuous supplies of healthy drinking water. Isolation and detection of a particular type of pathogen present at low concentration in a large volume of water, concentrating the analyte in a small detection volume, and removing detection inhibiting factors from the concentrated sample, present the three most important challenges for water quality monitoring laboratories. Combining advanced biological detection methods (e.g., nucleic acid-based or immunology-based protocols) with microfluidics and immunomagnetic separation techniques that exploit functionalized magnetic particles has tremendous potential for realization of an integrated system for pathogen detection, in particular, of waterborne pathogens. Taking advantage of the unique properties of magnetic particles, faster, more sensitive, and more economical diagnostic assays can be developed that can assist in the battle against microbial pathogenesis. In this review, we highlight current technologies and methods used for realization of magnetic particle-based microfluidic integrated waterborne pathogen isolation and detection systems, which have the potential to comply in future with regulatory water quality monitoring requirements.
机译：持续监测饮用水对于提供污染预警和确保持续供应健康饮用水极为重要。分离和检测大量水中低浓度存在的特定类型的病原体，以较小的检测量浓缩分析物以及从浓缩样品中去除检测抑制因子，这是水质监测实验室面临的三个最重要的挑战。将先进的生物检测方法（例如基于核酸或基于免疫学的方案）与利用功能化磁性颗粒的微流体和免疫磁分离技术相结合，对于实现病原体检测特别是水生病原体的集成系统具有巨大的潜力。利用磁性颗粒的独特特性，可以开发出更快，更灵敏和更经济的诊断分析方法，从而有助于对抗微生物发病机理。在这篇综述中，我们重点介绍了用于实现基于磁性颗粒的微流体集成水生病原体分离和检测系统的当前技术和方法，这些技术和方法有可能在将来符合监管水质监测要求。

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