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Cleaning-in-place validation issues

机译：就地清洗验证问题

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摘要

The technology of CIP (Cleaning-in-Place) has been employed in the dairy, food, pharmaceutical, medical, process and allied industries for many years. Systems have now become increasingly automated, which has given CIP systems a level of repeatability. This repeatability guarantees that a CIP clean is being carried out correctly. After proving - and commissioning - that the CIP cycles are operating effectively, the level of repeatability in some cases is relied upon to give implied 'proof' of the quality of the CIP cleans. To enable this repeatability to be relied upon the control system of the CIP should be validated. A validated system is basically a certified system which ensures that all aspects of the system have been subjected to full successful testing with each separate test certified once it has been completed. Once validation is completed it provides the assurance that the CIP will operate as expected, at all times, or in the case of equipment failure will inhibit cleans being completed when they are out of specification.
机译：CIP（就地清洁）技术已在乳制品，食品，制药，医疗，加工和相关行业中应用了很多年。系统现在变得越来越自动化，这使CIP系统具有一定的可重复性。这种可重复性保证了正确执行CIP清洁。在证明并调试CIP循环有效运行之后，在某些情况下，要依靠重复性的水平来暗示CIP清洁质量的“证明”。为了使这种可重复性依赖于CIP的控制系统，应进行验证。经过验证的系统基本上是经过认证的系统，可确保对系统的所有方面都进行全面成功的测试，并在完成每个单独的测试后对它进行认证。验证完成后，它可以确保CIP始终能够按预期运行，或者在设备故障的情况下，如果清洁不符合要求，清洁将无法完成。

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