Back to (non)-Basics: Recent Developments in Neutral and Charge-Balanced Glycosidase Inhibitors

Todd A. Houston  and Joanne T. Blanchfield

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Back to (non)-Basics: Recent Developments in Neutral and Charge-Balanced Glycosidase Inhibitors

机译：返回（非）基础知识：中性和电荷平衡型糖苷酶抑制剂的最新发展

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Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties.nGlyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimicnthe transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides andnsulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.

机译：某些糖苷酶抑制剂具有有效的抗病毒，抗肿瘤和抗糖尿病特性。已鉴定出的最早的糖苷酶抑制剂n甘氨酸内酯具有模仿糖苷水解过渡态的平面异头碳。其他类别包括内酰胺，糖基，环氧化物，卤化物和ns离子，后者基于来自抗糖尿病药草的天然产物Salacinol。

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来源
《Mini-Reviews in Medicinal Chemistry》 |2003年第7期|p.669-678|共10页
作者
Todd A. Houston and Joanne T. Blanchfield;
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作者单位

aSchool of Science, Griffith University, Nathan, QLD 4111, AustraliabSchool of Molecular and Microbial Sciences, University of Queensland, St. Lucia, QLD 4072, Australia;

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正文语种 eng
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关键词
Glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol;

机译：糖苷酶抑制剂;葡糖苷酶;甘露糖苷酶;半乳糖苷酶;唾液酸酶;水杨素;环糖醇;

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专利

1. Back to (non-)Basics: An Update on Neutral and Charge-Balanced Glycosidase Inhibitors [J] . Simone Michela I., Mares Laura J., Eveleens Clothilde A., Mini reviews in medicinal chemistry . 2018,第10期

机译：返回（非）基础知识：中性和电荷平衡糖苷酶抑制剂的更新
2. CYCLIC GUANIDINO-SUGARS WITH LOW PK(A) AS TRANSITION-STATE ANALOG INHIBITORS OF GLYCOSIDASES - NEUTRAL INSTEAD OF CHARGED SPECIES ARE THE ACTIVE FORMS [J] . Jeong JH, Murray BW, Takayama S, Journal of the American Chemical Society . 1996,第18期

机译：低PK（A）的环状胍基糖作为糖苷酶的过渡态类似物抑制剂-带电物种的中性替代是活跃形式
3. Chemical and chemo-enzymatic approaches to unnatural ketoses and glycosidase inhibitors with basic nitrogen in the sugar ring [J] . Fechter MH., Tauss A., Stutz AE. Current organic chemistry . 1999,第3期

机译：化学和化学酶法处理糖环中具有碱性氮的非天然酮糖和糖苷酶抑制剂
4. Development of a Neutral Multi-Metal Safe Aqueous Cleaner/Corrosion Inhibitor [C] . Gregg Sanko CleanTech'99: International Cleaning Technology Exposition, May 18-20, 1999, Rosemont, IL . 1999

机译：开发一种中性多金属安全水清洁剂/缓蚀剂
5. Insights into human neutral ceramidase transcription and the role of ceramide metabolism in the development of an inhibitor of restenosis. [D] . O'Neill, Sean Michael. 2009

机译：洞悉人类中性神经酰胺酶的转录以及神经酰胺代谢在再狭窄抑制剂发展中的作用。
6. Studies of the development of basic neutral and acidic isoenzymes of glutathione S-transferase in human liver adrenal kidney and spleen. [O] . C G Faulder, P A Hirrell, R Hume, 1987

机译：研究人肝肾上腺肾脏和脾脏中谷胱甘肽S-转移酶的碱性中性和酸性同工酶的发展。
7. Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis". [O] . Fournié-Zaluski, M C, Soleilhac, J M, Turcaud, S, 1992

机译：[125I] RB104（中性内肽酶24.11的有效抑制剂）的开发及其在通过“抑制剂凝胶电泳”检测纳克量的酶中的用途。
8. Specific Mechanism-Based Glycosidase Inhibitors as Chemoprotectants Against RicinToxicity [R] . Stohs, S. J. 1992

机译：基于特异性机制的糖苷酶抑制剂作为针对蓖麻毒素的化学保护剂

Back to (non)-Basics: Recent Developments in Neutral and Charge-Balanced Glycosidase Inhibitors

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