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首页> 外文期刊>Nano communication networks >Astrocyte-neuron communication as cascade of equivalent circuits
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Astrocyte-neuron communication as cascade of equivalent circuits

机译：星形细胞-神经元通讯作为等效电路的级联

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摘要

The propagation of the neural information in the cerebral cortex relies on the transfer of electrochemical impulses and diffusion of neurotransmitter molecules between neuron cells connected in a network through synaptic junctions. In this scenario, increasing interest is growing on the critical role of glia cells, in particular astrocytes, in supporting the neuronal communication. Neuroglias communicate to each other through calcium signaling and are able to sense the activity of adjacent neurons and release gliotransmitter molecules such as glutamate and D-serine, which bind on receptors located on the synaptic terminal of neurons. In other terms, astrocytes can potentially modulate the neuronal activity of adjacent neurons as well as distant neurons through calcium signaling. In this paper, we describe the neuron-astrocyte communication paradigm, first identifying the molecular processes constituting the communication and then representing each process with equivalent electronic circuits, characterized by frequency response. The aim of this work is to propose an alternative tool for the stimulus-response analysis of the astrocyte-neuron system, in particular to quantify the impact of astrocytic stimulation on the natural activity of spiking neurons. The frequency response of the equivalent circuits shows that certain stimulation patterns evoked through the astrocytes are more effective than others and have the potential of significantly alter the neuronal activity.
机译：神经信息在大脑皮层中的传播依赖于电化学脉冲的传递和神经递质分子在通过突触连接而连接到网络中的神经元细胞之间的扩散。在这种情况下，人们越来越关注神经胶质细胞（特别是星形胶质细胞）在支持神经元交流中的关键作用。神经胶质细胞通过钙信号传导相互交流，并能够感知相邻神经元的活性并释放神经胶质递质分子，例如谷氨酸和D-丝氨酸，它们结合在位于神经元突触末端的受体上。换句话说，星形胶质细胞可以通过钙信号传导潜在地调节邻近神经元和远处神经元的神经元活性。在本文中，我们描述了神经元-星形细胞通信范例，首先确定构成通信的分子过程，然后用等效电子电路（以频率响应为特征）表示每个过程。这项工作的目的是提出一种替代工具，用于星形胶质细胞-神经元系统的刺激反应分析，特别是量化星形胶质细胞刺激对突触神经元自然活动的影响。等效电路的频率响应表明，通过星形胶质细胞引起的某些刺激方式比其他方式更有效，并且具有显着改变神经元活动的潜力。

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  • 来源
    《Nano communication networks》 |2015年第4期|183-197|共15页
  • 作者

    Fabio Mesiti; Mladen Veletic; Pal Anders Floor; Ilangko Balasingham;

  • 作者单位

    Department of Electronics and Telecommunications, Norwegian University of Science and Technology (NTNU), Norway,Institute of Clinical Medicine, University of Oslo, Norway,IET-NTNU, 7491 - Trondheim, Norway;

    Department of Electronics and Telecommunications, Norwegian University of Science and Technology (NTNU), Norway,Faculty of Electrical Engineering, University of Banja Luka, Bosnia and Herzegovina;

    Intervention Center, Oslo University Hospital, Norway,Institute of Clinical Medicine, University of Oslo, Norway;

    Department of Electronics and Telecommunications, Norwegian University of Science and Technology (NTNU), Norway,Intervention Center, Oslo University Hospital, Norway,Institute of Clinical Medicine, University of Oslo, Norway;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Neurons; Astrocytes; Tripartite synapse; Neuronal stimulation; Nanomachine-neuron interface;

    机译：神经元;星形胶质细胞三方突触;神经元刺激;纳米机-神经元接口;

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