Laser-Based Gene Transfection and Gene Therapy

Yao C.-P.; Zhang Z.-X.; Rahmanzadeh R.; Huettmann G.

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Laser-Based Gene Transfection and Gene Therapy

机译：基于激光的基因转染和基因治疗

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The plasma membrane of mammalian cells can be transiently permeablized by optical means and exogenous materials or genes can be introduced into the cytoplasm of living cells. Until now, few mechanisms were exploited for the manipulation: laser is directly and tightly focused on the cells for optoinjection, laser-induced stress waves, photochemical internalization, and irradiation of selective cell targeting with light-absorbing particles. During the past few years, extensive progress and numerous breakthroughs have been made in this area of research. This review covers four different laser-assisted transfection techniques and their advantages and disadvantages. Universality towards various cell lines is possibly the main advantage of laser-assisted optoporation in comparison with presently existing methods of cell transfection.

机译：哺乳动物细胞的质膜可以通过光学手段瞬时渗透，并且可以将外源材料或基因引入活细胞的细胞质中。到现在为止，很少有机制被利用：激光直接和紧密地聚焦在细胞上进行光注入，激光诱导的应力波，光化学内在化以及用光吸收粒子照射选择性细胞。在过去的几年中，在这一研究领域取得了广泛的进展和许多突破。这篇综述涵盖了四种不同的激光辅助转染技术及其优缺点。与目前存在的细胞转染方法相比，对各种细胞系的通用性可能是激光辅助对映作用的主要优势。

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《IEEE transactions on nanobioscience》 |2008年第2期|p.111-119|共9页
作者
Yao C.-P.; Zhang Z.-X.; Rahmanzadeh R.; Huettmann G.;
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Laser-Based Gene Transfection and Gene Therapy

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