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首页> 外文期刊>Nanobiotechnology, IET >Bacteriocin-capped silver nanoparticles for enhanced antimicrobial efficacy against food pathogens
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Bacteriocin-capped silver nanoparticles for enhanced antimicrobial efficacy against food pathogens

机译：细菌粘接银纳米颗粒，用于增强对食品病原体的抗微生物疗效

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Bacteriocins produced by lactic acid bacteria are safer alternatives to the more popularly used chemical preservatives which exhibit several adverse effects. The bacteriocins have an advantage of being efficient in controlling food pathogens without possessing any side-effects. However, the bacteriocins have a limitation of exhibiting a narrow antimicrobial spectrum and having a high-dosage requirement. With an aim to combat these limitations, the present study involved the biosynthesis of bacteriocin-capped nanoparticles, using two bacteriocins (Bac4463 and Bac22) extracted and purified from Lactobacillus strains. Nanoconjugates synthesised at optimum conditions were characterized using various physico-chemical techniques. The interaction of bacteriocin-capped silver nanoparticles with the pathogenic bacteria was observed using scanning electron microscopy, wherein the deformed and elongated cells were clearly visible. In vitro antimicrobial efficacy of both Bac4463-capped silver nanoparticles and Bac22-capped silver nanoparticles against different food pathogens was observed to be enhanced in comparison to the antimicrobial activity of bacteriocins alone. Minimum inhibitory concentration was observed to be as low as 8 mu g/ml for Bac4463-capped silver nanoparticles against Staphylococcus aureus, and 2 mu g/ml for Bac22-capped silver nanoparticles against Shigella flexneri. This study, therefore, recommends the use of bacteriocin-capped nanoparticles as food preservatives to control the growth of food spoiling bacteria.
机译：由乳酸菌产生的菌株是更普遍使用的化学防腐剂的更安全的替代品，其表现出几种不良反应。细菌偶联具有有效控制食品病原体而不具有任何副作用的优点。然而，细菌素具有呈现窄抗微生物谱并具有高剂量要求的限制。目前，本研究涉及使用两种菌丝（Bac4463和Bac22）从乳杆菌菌株中萃取和纯化的菌谱纳米粒子的生物合成。使用各种物理化学技术在最佳条件下合成的纳米缀合物。使用扫描电子显微镜观察细菌谱覆盖银纳米粒子与致病细菌的相互作用，其中变形和细长的细胞清晰可见。与单独的细菌素的抗微生物活性相比，观察到Bac4463封端的银纳米粒子和Bac22-Lappe银纳米粒子的体外抗菌效果和Bac22-Lappe银纳米颗粒。将最小抑制浓度观察到抑制葡萄球菌的Bac4463封端的银纳米颗粒，以及2μg/ ml的Bac22-Lapped银纳米粒子对志贺氏菌柔屈菌的8μg/ ml。因此，本研究建议使用含有细菌型纳米粒子作为食品防腐剂以控制食物破坏细菌的生长。

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