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首页> 外文期刊>Nanobiotechnology, IET >Gentamicin-gold nanoparticles conjugate: a contrast agent for X-ray imaging of infectious foci due to Staphylococcus aureus
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Gentamicin-gold nanoparticles conjugate: a contrast agent for X-ray imaging of infectious foci due to Staphylococcus aureus

机译：庆大霉素-金纳米颗粒偶联物：X射线成像的金黄色葡萄球菌感染灶的造影剂

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摘要

There is no optimal imaging method for the detection of unknown infectious foci in some diseases. This study introduces a novel method in X-ray imaging of infection foci due to Staphylococcus aureus by developing a contrast agent based on gold nanoparticles (GNPs). GNPs in spherical shape were synthesised by the reduction of tetrachloroauric acid with sodium citrate. Then gentamicin was bound directly to citrate functionalised GNPs and the complex was stabilised by polyethylene glycol. The interaction of gentamicin with GNPs was confirmed by ultraviolet-visible and Fourier transform infrared spectroscopies. The stability of complex was studied in human blood up to 6 h. The stability of conjugate was found to be high in human blood with no aggregation. The biodistribution study showed localisation of gentamicin-GNPs conjugate at the site of Staphylococcal infection. The infection site was properly visualised in X-ray images in mouse model using the gentamicin-GNPs conjugate as a contrast agent. The results demonstrated that one may consider the potential of new nanodrug as a contrast agent for X-ray imaging of infection foci in human beings which needs more investigations.
机译：没有检测某些疾病中未知传染源的最佳成像方法。这项研究通过开发一种基于金纳米颗粒（GNP）的造影剂，在X射线成像中对金黄色葡萄球菌引起的感染灶进行了介绍。通过用柠檬酸钠还原四氯金酸来合成球形GNP。然后将庆大霉素直接结合到柠檬酸盐官能化的GNP上，并用聚乙二醇稳定该复合物。庆大霉素与GNP的相互作用已通过紫外可见光谱和傅里叶变换红外光谱证实。研究了复合物在人体血液中长达6小时的稳定性。发现缀合物在人血液中的稳定性高，没有聚集。生物分布研究表明，庆大霉素-GNPs共轭物位于葡萄球菌感染部位。使用庆大霉素-GNPs偶联物作为造影剂，可以在小鼠模型的X射线图像中正确显示感染部位。结果表明，人们可能会考虑将新的纳米药物作为人类感染灶的X射线成像造影剂的潜力，这需要更多的研究。

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