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Emerging microfluidic devices for cancer cells/biomarkers manipulation and detection

机译:用于癌细胞/生物标志物操纵和检测的新兴微流控设备

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Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ~90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major technological challenge. Microfluidic technologies have opened-up new opportunities for the screening of blood samples and the detection of CTCs or other important cancer biomarker-proteins. In this study, the authors have reviewed the most recent developments in microfluidic devices for cells/biomarkers manipulation and detection, focusing their attention on immunomagnetic-affinity-based devices, dielectrophoresis-based devices, surface-plasmon-resonance microfluidic sensors, and quantum-dots-based sensors.
机译:循环肿瘤细胞(CTC)是转移过程的积极参与者,约占所有癌症死亡人数的90%。由于四氯化碳与血液中大量的红细胞,白细胞和血小板混合在一起,因此四氯化碳非常罕见,使其分离,捕获和检测成为一项重大技术挑战。微流体技术为筛查血液样本和检测CTC或其他重要的癌症生物标志物蛋白开辟了新的机会。在这项研究中,作者回顾了用于细胞/生物标记物操作和检测的微流控设备的最新进展,将注意力集中在基于免疫磁亲和力的设备,基于介电电泳的设备,表面等离子体共振微流控传感器以及量子微电子技术上。基于点的传感器。

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