Evaluation of the wound healing efficacy of chemical and phytogenic silver nanoparticles

Sreevani Pothireddy; Adilaxmamma Kaliki; Alpha Raj Mekapogu; Muralidhar Yegireddy; Eswara Prasad Pagadala; Tollamadugu Naga Venkata Krishna Vara Prasad

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Evaluation of the wound healing efficacy of chemical and phytogenic silver nanoparticles

机译：化学和植物性银纳米颗粒对伤口愈合功效的评估

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Wound healing requires a series of cellular events and a cascade of co-ordinated and systemic biochemical events. Silver nanoparticles possess many beneficial properties for wound management including antibacterial, anti-inflammatory and pro-healing properties. In this study, the authors investigated the wound healing properties of Cinnamomum verum extract mediated nanosilver (CENS) particles in comparison with 1% povidone iodine, citrate mediate NS and CE treatments. The topical application of CENS showed good antibacterial activity and accelerated wound healing with complete epithelialisation and normal re-growth of hair in all three models of study: namely, excision, incision and dead space models in rats compared with all other treatments. CENS was also found to promote collagen synthesis, stabilise wound besides countering oxidative stress and stimulating cellular proliferation CENS could be a novel therapeutic agent for wound management.

机译：伤口愈合需要一系列细胞事件以及一系列协调的和全身性的生化事件。银纳米颗粒具有许多有益于伤口处理的特性，包括抗菌，消炎和促愈特性。在这项研究中，作者调查了肉桂提取物介导的纳米银（CENS）颗粒与1％聚维酮碘，柠檬酸盐介导的NS和CE治疗相比的伤口愈合特性。与所有其他治疗方法相比，在所有三种研究模型中，即在大鼠的切除，切口和死腔模型中，CENS的局部应用均显示出良好的抗菌活性和加速的伤口愈合，具有完全的上皮化和正常的头发再生长。还发现CENS可以促进胶原蛋白的合成，除了抗氧化应激和刺激细胞增殖外，还可以稳定伤口。CENS可以作为伤口处理的新型治疗剂。

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来源
《Nanobiotechnology, IET》 |2016年第5期|340-348|共9页
作者
Sreevani Pothireddy; Adilaxmamma Kaliki; Alpha Raj Mekapogu; Muralidhar Yegireddy; Eswara Prasad Pagadala; Tollamadugu Naga Venkata Krishna Vara Prasad;
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作者单位

College of Veterinary Science, India;

College of Veterinary Science, India;

College of Veterinary Science, India;

College of Veterinary Science, India;

College of Veterinary Science, India;

Regional Agricultural Research Station, India;

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正文语种 eng
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wounds; antibacterial activity; biochemistry; biomedical materials; cellular biophysics; nanomedicine; nanoparticles; proteins; silver;

机译：伤口;抗菌活性;生化;生物医学材料;细胞生物物理学;纳米药物;纳米颗粒;蛋白质;银;

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1. Evaluation of the antimicrobial efficacy of phytogenic silver nanoparticles [J] . Prasad TNVKV, Elumalai EK, Khateeja S 亚太热带生物医学杂志（英文版） . 2011,第0z1期

机译：植物性银纳米颗粒的抗菌功效评估
2. Catalytic, antibacterial and antibiofilm efficacy of biosynthesised silver nanoparticles using Prosopis juliflora leaf extract along with their wound healing potential [J] . Arya Geeta, Kumari R. Mankamna, Sharma Nikita, Journal of Photochemistry and Photobiology, B. Biology: Official Journal of the European Society for Photobiology . 2019,第期

机译：使用ProsoPIS Juliflora叶提取物以及伤口愈合潜力，生物合成银纳米粒子的催化，抗菌和抗菌和抗菌菌株的疗效
3. Composite of silver nanoparticles and photosensitizer leads to mutual enhancement of antimicrobial efficacy and promotes wound healing [J] . Chen Jingyi, Yang Ling, Chen Jincan, Chemical engineering journal . 2019,第期

机译：银纳米粒子和光敏剂的复合材料导致抗微生物功效的相互增强，促进伤口愈合
4. Antibacterial effect and wound healing ability of silver nanoparticles green synthesized by iturin [C] . Xixi Zhao, Liangfu Zhou, Chongyang Ai, International Conference on Biological Information and Biomedical Engineering . 2019

机译：Iturin合成银纳米粒子绿色的抗菌效果和伤口愈合能力
5. Cytotoxic evaluation and factorial analysis of three-dimensional photopolymerizable thermoresponsive composite nanoparticle hydrogels for controlled drug delivery in restenosis and wound healing. [D] . Sabnis, Abhimanyu Rajaram. 2007

机译：三维光聚合热响应性复合纳米颗粒水凝胶在再狭窄和伤口愈合中可控药物递送的细胞毒性评估和因子分析。
6. Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model [O] . Vajravathi Lakkim, Madhava C. Reddy, Roja Rani Pallavali, 2020

机译：银纳米粒子的绿色合成及其对多药抗菌和伤口愈合疗效的评价使用鼠模型
7. A macro-and microscopic local effect of silver nanoparticles on skin wound healing and some biochemical parameters of blood in mice [O] . Rahnama S., Heydarnejad M.S., Mobini-Dehkordi M., 2014

机译：银纳米颗粒对小鼠皮肤伤口愈合和血液某些生化参数的宏观和微观局部影响

Evaluation of the wound healing efficacy of chemical and phytogenic silver nanoparticles

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