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首页> 外文期刊>Nanobiotechnology, IET >Postprandial anti-hyperglycemic activity of marine Streptomyces coelicoflavus SRBVIT13 mediated gold nanoparticles in streptozotocin induced diabetic male albino Wister rats
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Postprandial anti-hyperglycemic activity of marine Streptomyces coelicoflavus SRBVIT13 mediated gold nanoparticles in streptozotocin induced diabetic male albino Wister rats

机译：链脲佐菌素诱导的糖尿病雄性白化病Wister大鼠海洋链霉菌Coelicoflavus SRBVIT13介导的金纳米粒子的餐后降血糖活性

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摘要

The present study focuses on the biosynthesis of gold nanoparticles (AuNPs) using Streptomyces coelicoflavus (S. coelicoflavus) SRBVIT13 isolated from marine salt pan soils collected from Ongole, Andhra Pradesh, India. The biosynthesised AuNPs are characterised by UV-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy and energy-dispersive X-ray analysis. Transmission electron microscopy study suggests that the biosynthesised AuNPs are spherical in shape within a size range of 12-20 nm (mean diameter as 14 nm). The anti-type II diabetes activity of AuNPs is carried out by testing it in vitro α-glucosidase and α-amylase enzyme inhibition activity and in vivo postprandial anti-hyperglycemic activity in sucrose and glucose-loaded streptozotocin induced diabetic albino Wister rats. AuNPs has shown a significant inhibitory activity of 84.70 and 87.82% with IC50 values of 67.65 and 65.59 μg/mL to α-glucosidase and α-amylase enzymes, while the diabetic rats have shown significant reduction in the post postprandial blood glucose level by 57.80 and 88.09%, respectively compared with control group after AuNPs treatment at the concentration of 300 and 600 mg/kg body weight. Hence, this biosynthesised AuNPs might be useful in combating type II diabetes mellitus for the betterment of human life.
机译：本研究的重点是使用分离自印度安得拉邦昂戈尔的海盐盘土壤中分离出的Streptomyces coelicoflavus（S. coelicoflavus）SRBVIT13进行金纳米颗粒（AuNPs）的生物合成。生物合成的金纳米粒子的特征在于紫外可见光谱，X射线衍射，傅立叶变换红外光谱，高分辨率透射电子显微镜和能量色散X射线分析。透射电子显微镜研究表明，生物合成的AuNP在大小范围为12-20 nm（平均直径为14 nm）内呈球形。 AuNPs的抗II型糖尿病活性是通过在蔗糖和葡萄糖加载的链脲佐菌素诱导的糖尿病白化病Wister大鼠中测试其体外α-葡萄糖苷酶和α-淀粉酶的抑制活性以及体内餐后抗高血糖活性来进行的。 AuNPs对α-葡萄糖苷酶和α-淀粉酶的抑制活性分别为84.70％和87.82％，IC50值为67.65和65.59μg/ mL，而糖尿病大鼠的餐后血糖水平则显着降低了57.80和AuNPs治疗浓度分别为300和600 mg / kg体重后，与对照组相比分别为88.09％。因此，这种生物合成的AuNPs可能有助于抗击II型糖尿病，改善人类生活。

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