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In-vitro toxicity of carbon nanotube/polylysine colloids to colon cancer cells

机译：碳纳米管/聚赖氨酸胶体对结肠癌细胞的体外毒性

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Single-walled carbon nanotubes (SWCNTs) are thoroughly purified and dispersed in an aqueous solution of high molecular weight poly-L-lysine (pLlys). Human intestinal epithelial Caco-2/TC7 cells are incubated with the SWCNT dispersions in pLlys, and their effects on cell viability are studied by image flow cytometry. No significant changes are observed in the cell culture wells up to pLlys concentrations of 10 μg ml−1. However, high mortality is detected at pLlys concentrations of 100 μg ml−1. The presence of oxygen-free SWCNTs does not modify the effects of pLlys on cell cultures at any of the tested concentrations (≤1 μg ml−1). In addition, SWCNTs having an 8 wt.% of surface oxygen are tested with identical results. Thus, purified SWCNTs, even bearing oxygen functional groups, act as inert particles in the cell culture medium. This result supports the applicability of SWCNTs as carriers in pharmacological formulations against digestive tract diseases.
机译：将单壁碳纳米管（SWCNT）彻底纯化并分散在高分子量聚L-赖氨酸（pLlys）的水溶液中。将人肠上皮Caco-2 / TC7细胞与SWCNT分散液在pLlys中孵育，并通过图像流式细胞术研究其对细胞生存力的影响。在10μgml-1的pLlys浓度下，细胞培养孔中未观察到明显变化。但是，在100μgml-1的pLlys浓度下检测到高死亡率。在任何测试浓度（≤1μgml-1）中，无氧SWCNT的存在都不会改变pLlys对细胞培养的影响。另外，测试具有8重量％的表面氧的SWCNT具有相同的结果。因此，甚至带有氧官能团的纯化的SWCNT在细胞培养基中充当惰性颗粒。该结果支持SWCNT在药物制剂中作为载体抵抗消化道疾病的适用性。

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