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首页> 外文期刊>Nanobiotechnology, IET >Biogenic synthesis of silver nanoparticles from Cassia fistula (Linn.): In vitro assessment of their antioxidant, antimicrobial and cytotoxic activities
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Biogenic synthesis of silver nanoparticles from Cassia fistula (Linn.): In vitro assessment of their antioxidant, antimicrobial and cytotoxic activities

机译：决明子瘘（Linn。）的生物合成银纳米颗粒：体外评估其抗氧化，抗微生物和细胞毒性活性

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摘要

The present study reports on biogenic-synthesised silver nanoparticles (AgNPs) derived by treating Ag ions with an extract of Cassia fistula leaf, a popular Indian medicinal plant found in natural habitation. The progress of biogenic synthesis was monitored time to time using a ultraviolet–visible spectroscopy. The effect of phytochemicals present in C. fistula including flavonoids, tannins, phenolic compounds and alkaloids on the homogeneous growth of AgNPs was investigated by Fourier-transform infrared spectroscopy. The dynamic light scattering studies have revealed an average size and surface Zeta potential of the NPs as, −39.5 nm and −21.6 mV, respectively. The potential antibacterial and antifungal activities of the AgNPs were evaluated against Bacillus subtilis, Staphylococcus aureus, Candida kruseii and Trichophyton mentagrophytes. Moreover, their strong antioxidant capability was determined by radical scavenging methods (1,1-diphenyl-2-picryl-hydrazil assay). Furthermore, the AgNPs displayed an effective cytotoxicity against A-431 skin cancer cell line by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, with the inhibitory concentration (IC50) predicted as, 92.2 ± 1.2 μg/ml. The biogenically derived AgNPs could find immense scope as antimicrobial, antioxidant and anticancer agents apart from their potential use in chemical sensors and translational medicine.
机译：本研究报告了通过用决明子叶提取物处理Ag离子而获得的生物合成的银纳米颗粒（AgNPs），决明子叶是一种在自然栖息地发现的流行印度药用植物。使用紫外可见光谱仪不时监测生物合成的进展。通过傅立叶变换红外光谱法研究了瘘管中存在的植物化学物质（包括类黄酮，单宁，酚类化合物和生物碱）对AgNPs均匀生长的影响。动态光散射研究表明，NP的平均大小和表面Zeta电位分别为-39.5 nm和-21.6 mV。评估了AgNPs对枯草芽孢杆菌，金黄色葡萄球菌，克鲁斯假丝酵母和毛癣菌的潜在抗菌和抗真菌活性。此外，它们的强抗氧化能力是通过自由基清除方法（1,1-二苯基-2-吡啶-肼试验）确定的。此外，AgNPs通过3-（4，5-二甲基噻唑-2-基）-2，5-二苯基四唑溴化物（MTT）测定对A-431皮肤癌细胞系表现出有效的细胞毒性，并预测了抑制浓度（IC50）含量为92.2±1.2μg/ ml。除了在化学传感器和转化医学中的潜在用途外，从生物上衍生的AgNPs还可以作为抗菌剂，抗氧化剂和抗癌剂找到巨大的范围。

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