Short interfering RNA therapeutics: nanocarriers, prospects and limitations

Mehrotra Neha; Tripathi Ravi Mani

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Short interfering RNA therapeutics: nanocarriers, prospects and limitations

机译：短干扰RNA疗法：纳米载体，前景和局限性

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Since the first experiment depicting gene inhibition using RNA interference mechanism, extensive research has been carried out to design targeted delivery systems that use short interfering RNAs (siRNAs) for gene expression regulation. Although several siRNAs loaded nanoparticle systems have reached clinical trial stage, cellular uptake, reticuloendothelial entrapment and endosomal escape still limit the efficacy of these drugs considerably. This review discusses about the RNA interference mechanism, nanostructures being used as non-viral vectors for targeted delivery, limitations of the common delivery systems and the current siRNA-loaded nanoparticle formulations undergoing clinical testing.

机译：自从使用RNA干扰机制描述基因抑制的第一个实验以来，已经进行了广泛的研究来设计使用短干扰RNA（siRNA）进行基因表达调控的靶向递送系统。尽管几种载有siRNA的纳米颗粒系统已进入临床试验阶段，但细胞摄取，网状内皮捕获和内体逃逸仍大大限制了这些药物的疗效。这篇综述讨论了RNA干扰机制，用作非病毒载体进行靶向递送的纳米结构，常见递送系统的局限性以及目前正在接受临床测试的载有siRNA的纳米颗粒制剂。

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《Nanobiotechnology, IET》 |2015年第6期|386-395|共10页
作者
Mehrotra Neha; Tripathi Ravi Mani;
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Amity University, India;

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机译：基于脂质的纳米载体，用于递送小干扰RNA治疗使用
2. Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-l-lysine nanocarrier to suppress prostate cancer growth in mice [J] . GuoJ., ChengW.P., GuJ., European journal of pharmaceutical sciences . 2012,第5期

机译：使用pH触发的两亲性聚赖氨酸纳米载体系统递送治疗性小干扰RNA，以抑制小鼠前列腺癌的生长
3. Molecular and Coarse-Grained Modeling to Characterize and Optimize Dendrimer-Based Nanocarriers for Short Interfering RNA Delivery [J] . Filip Stojceski, Gianvito Grasso, Lorenzo Pallante, ACS Omega . 2020,第6期

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机译：可治疗动物反义microRNA的可生物降解聚合物纳米载体。
5. Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors [D] . Waite, Carolyn Leigh 2011

机译：工程化靶向肿瘤的聚（酰胺基胺）（PAMAM）树状大分子，以提高短干扰RNA（siRNA）通过实体瘤的渗透和细胞递送
6. Molecular and Coarse-Grained Modeling to Characterizeand Optimize Dendrimer-Based Nanocarriers for Short Interfering RNADelivery [O] . Filip Stojceski, Gianvito Grasso, Lorenzo Pallante, 2020

机译：分子和粗粒度建模来表征和优化基于树状聚合物的纳米载体用于短干扰RNA交货
7. Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice [O] . Guo Jianfeng, Cheng Woei Ping, Gu Jingxia, 2013

机译：使用pH触发的两亲性聚L-赖氨酸纳米载体全身递送治疗性小干扰RNA，以抑制小鼠前列腺癌的生长

Short interfering RNA therapeutics: nanocarriers, prospects and limitations

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