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Preparation, characterisation and antibacterial activity of a florfenicol-loaded solid lipid nanoparticle suspension

机译：氟苯尼考固体脂质纳米粒悬浮液的制备，表征和抑菌活性

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摘要

A florfenicol-loaded solid lipid nanoparticle (FFC-SLN) suspension was prepared by hot homogenisation and ultrasonic technique. The suspension was characterised for its release profile, stability, toxicity, and the physicochemical properties of the nanoparticles. Antibacterial activity of the suspension was evaluated and . The results showed that the mean diameter, polydispersity index and zeta potential of the nanoparticles were 253 ± 3 nm, 0.409 ± 0.022 and 47.5 ± 0.21 mV, respectively. release profile showed the FFC-SLN suspension had sustained release effect. The minimum inhibition concentration values of the FFC-SLN suspension were 6 and 3 µg/mL against and respectively, compared with 3.5 and 2 µg/mL of native florfenicol. The suspension was relatively stable at 4°C and less stable at room temperature during 9 months storage. Although the nanoparticle carriers exhibited cytotoxicity in cell cultures, the LD of the lyophilised dry power of the suspension was higher than 5 g/kg body weight. Mortality protection against lethal infection in mice showed that the nanoparticle suspension had much better efficacy (6/10) than native drug (1/10). These results indicate that FFC-SLN suspension could be a promising formulation in veterinary medicine.
机译：通过热均化和超声技术制备了氟苯尼考的​​固体脂质纳米颗粒（FFC-SLN）悬浮液。对悬浮液的释放特性，稳定性，毒性和纳米颗粒的理化特性进行了表征。评价了该悬浮液的抗菌活性。结果表明，纳米颗粒的平均直径，多分散指数和ζ电势分别为253±3nm，0.409±0.022和47.5±0.21mV。释放曲线表明FFC-SLN悬浮液具有持续释放作用。 FFC-SLN悬浮液的最小抑菌浓度分别为0.5和2 µg / mL，而天然氟苯尼考分别为6和3 µg / mL。该悬浮液在4℃下相对稳定，并且在9个月的储存期间在室温下较不稳定。尽管纳米颗粒载体在细胞培养物中显示出细胞毒性，但是该悬浮液的冻干干粉的LD高于5g / kg体重。对小鼠致死性感染的死亡率保护表明，纳米颗粒悬浮液的功效（6/10）比天然药物（1/10）好得多。这些结果表明FFC-SLN悬浮液可能是兽医学中有希望的制剂。

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