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首页> 外文期刊>Nanobiotechnology, IET >Experimental investigation of magnetically actuated separation using tangential microfluidic channels and magnetic nanoparticles
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Experimental investigation of magnetically actuated separation using tangential microfluidic channels and magnetic nanoparticles

机译：切向微流体通道和磁性纳米粒子进行磁驱动分离的实验研究

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A novel continuous switching/separation scheme of magnetic nanoparticles (MNPs) in a sub-microlitre fluid volume surrounded by neodymium permanent magnet is studied in this work using tangential microfluidic channels. Polydimethylsiloxane tangential microchannels are fabricated using a novel micromoulding technique that can be done without a clean room and at much lower cost and time. Negligible switching of MNPs is seen in the absence of magnetic field, whereas 90% of switching is observed in the presence of magnetic field. The flow rate of MNPs solution had dramatic impact on separation performance. An optimum value of the flow rate is found that resulted in providing effective MNP separation at much faster rate. Separation performance is also investigated for a mixture containing non-magnetic polystyrene particles and MNPs. It is found that MNPs preferentially moved from lower microchannel to upper microchannel resulting in efficient separation. The proof-of-concept experiments performed in this work demonstrates that microfluidic bioseparation can be efficiently achieved using functionalised MNPs, together with tangential microchannels, appropriate magnetic field strength and optimum flow rates. This work verifies that a simple low-cost magnetic switching scheme can be potentially of great utility for the separation and detection of biomolecules in microfluidic lab-on-a-chip systems.
机译：在这项工作中，使用切向微流体通道研究了一种亚微升流体体积中被钕永磁体包围的磁性纳米颗粒（MNP）的新型连续切换/分离方案。聚二甲基硅氧烷切向微通道是使用新型微模塑技术制造的，该技术无需清洁室即可完成，且成本和时间低得多。在不存在磁场的情况下，MNP的切换可忽略不计，而在存在磁场的情况下，观察到90％的切换。 MNPs溶液的流速对分离性能有重大影响。发现流速的最佳值，可以以更快的速度提供有效的MNP分离。还研究了包含非磁性聚苯乙烯颗粒和MNP的混合物的分离性能。发现MNP优先从下部微通道移动到上部微通道，导致有效分离。在这项工作中进行的概念验证实验表明，使用功能化的MNP以及切向微通道，适当的磁场强度和最佳流速可以有效地实现微流体生物分离。这项工作验证了一种简单的低成本磁性开关方案，对于微流控芯片实验室系统中生物分子的分离和检测，可能具有巨大的实用性。

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