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首页> 外文期刊>Nanobiotechnology, IET >Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling
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Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling

机译：无线和无电池生物医学微系统，用于基于大脑局部冷却的神经记录和癫痫抑制

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摘要

This work presents a biomedical microsystem with a wireless radiofrequency (RF)-powered electronics and versatile sensors/actuators for use in nanomedicinal diagnosis and therapy. The cooling of brain tissue has the potential to reduce the frequency and severity of epilepsy. Miniaturised spiral coils as a wireless power module with low-dropout linear regulator circuit convert RF signals into a DC voltage, can be implanted without a battery in monitoring free behaviour. A thermoelectric (TE) cooler is an actuator that is employed to cool down brain tissue to suppress epilepsy. Electroencephalogram (EEG) electrodes and TE coolers are integrated to form module that is placed inside the head of a rat and fastened with a biocompatible material. EEG signals are used to identify waveforms associated with epilepsy and are measured using readout circuits. The wireless part of the presented design achieves a low quiescent current and line/load regulation and high antenna/ current efficiency with thermal protection to avoid damage to the implanted tissue. Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode. Related characterisations demonstrate that the proposed design can be adopted in an effective nanomedicine microsystem.
机译：这项工作提出了一种生物医学微系统，该系统具有无线射频（RF）供电的电子设备和用于纳米医学诊断和治疗的多功能传感器/执行器。脑组织的冷却有可能降低癫痫的发生频率和严重程度。微型螺旋线圈作为具有低压差线性稳压器电路的无线电源模块，可将RF信号转换为DC电压，无需电池即可植入，以监视自由行为。热电（TE）冷却器是一种致动器，用于冷却大脑组织以抑制癫痫发作。脑电图（EEG）电极和TE冷却器集成在一起，形成模块，该模块放置在大鼠的头部内，并用生物相容性材料固定。 EEG信号用于识别与癫痫相关的波形，并使用读出电路进行测量。所提出设计的无线部分实现了低静态电流和线路/负载调节以及高天线/电流效率以及热保护，从而避免了对植入组织的损害。降低温度以减少癫痫发作的持续时间可抑制癫痫发作。相关特征表明，提出的设计可以在有效的纳米药物微系统中采用。

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