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Electromechanical vortex filaments during cardiac fibrillation

机译：心脏纤颤期间的机电涡流丝

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摘要

The self-organized dynamics of vortex-like rotating waves, which are also known as scroll waves, are the basis of the formation of complex spatiotemporal patterns in many excitable chemical and biological systems(1-4). In the heart, filament-like phase singularities(5,6) that are associated with three-dimensional scroll waves(7) are considered to be the organizing centres of life-threatening cardiac arrhythmias(7-13). The mechanisms that underlie the onset, maintenance and control(14-16) of electromechanical turbulence in the heart are inherently three-dimensional phenomena. However, it has not previously been possible to visualize the three-dimensional spatiotemporal dynamics of scroll waves inside cardiac tissues. Here we show that three-dimensional mechanical scroll waves and filament-like phase singularities can be observed deep inside the contracting heart wall using high-resolution four-dimensional ultrasound-based strain imaging. We found that mechanical phase singularities co-exist with electrical phase singularities during cardiac fibrillation. We investigated the dynamics of electrical and mechanical phase singularities by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart. We show that cardiac fibrillation can be characterized using the three-dimensional spatiotemporal dynamics of mechanical phase singularities, which arise inside the fibrillating contracting ventricular wall. We demonstrate that electrical and mechanical phase singularities show complex interactions and we characterize their dynamics in terms of trajectories, topological charge and lifetime. We anticipate that our findings will provide novel perspectives for non-invasive diagnostic imaging and therapeutic applications.
机译：旋涡状旋转波的自组织动力学也称为涡旋波，是许多可激发化学和生物系统中复杂时空模式形成的基础（1-4）。在心脏中，与三维滚动波（7）相关联的细丝状相奇点（5,6）被认为是威胁生命的心律不齐的组织中心（7-13）。心脏内机电湍流的发作，维持和控制的机制（14-16）本质上是三维现象。但是，以前不可能可视化心脏组织内部涡旋波的三维时空动力学。在这里，我们显示可以使用高分辨率的基于二维超声的应变成像在收缩的心脏壁内部深处观察到三维机械滚动波和细丝状相奇点。我们发现在心脏纤颤期间机械相奇异点与电气相奇异点并存。通过同时测量膜电位，细胞内钙浓度和心脏的机械收缩，我们研究了电和机械相奇异点的动力学。我们表明，心脏纤颤可以使用机械相奇异点的三维时空动力学来表征，这是在纤颤性收缩性心室壁内部出现的。我们证明了电气和机械相奇异点显示出复杂的相互作用，并且我们根据轨迹，拓扑电荷和寿命来表征它们的动力学。我们预计我们的发现将为非侵入性诊断成像和治疗应用提供新颖的观点。

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  • 来源
    《Nature》 |2018年第7698期|667-672|共6页
  • 作者

    Christoph J.; Chebbok M.; Richter C.; Schroeder-Schetelig J.; Bittihn P.; Stein S.; Uzelac I.; Fenton F. H.; Hasenfuss G.; Gilmour R. F. Jr.; Luther S.;

  • 作者单位

    Max Planck Inst Dynam & Self Org, Gottingen, Germany;

    German Ctr Cardiovasc Res DZHK, Partner Site Gottingen, Gottingen, Germany;

    Max Planck Inst Dynam & Self Org, Gottingen, Germany;

    Max Planck Inst Dynam & Self Org, Gottingen, Germany;

    Univ Calif San Diego, BioCircuits Inst, La Jolla, CA 92093 USA;

    Max Planck Inst Dynam & Self Org, Gottingen, Germany;

    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA;

    Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA;

    German Ctr Cardiovasc Res DZHK, Partner Site Gottingen, Gottingen, Germany;

    Univ Prince Edward Isl, Charlottetown, PE, Canada;

    Max Planck Inst Dynam & Self Org, Gottingen, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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