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首页> 外文期刊>Nature >Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

机译：由蝙蝠起源的HKU2相关冠状病毒引起的致命猪急性腹泻综合征

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摘要

Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health(1). Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)(2-10). Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
机译：野生动植物库中病毒的跨物种传播对人类和动物健康构成了明显威胁（1）。蝙蝠是公认的新兴病毒最重要的宿主之一，而起源于蝙蝠的冠状病毒通过中间宿主向人类的传播是造成高影响力的新兴人畜共患病，严重急性呼吸系统综合症（SARS）的原因（2-10） ）。在这里，我们提供病毒学，流行病学，进化论和实验证据，证明一种新型的与HKU2相关的蝙蝠冠状病毒，即猪急性腹泻综合征冠状病毒（SADS-CoV），是导致猪致命性疾病大规模爆发的病原体。中国已经导致四个农场的24,693头仔猪死亡。值得注意的是，爆发是在SARS大流行起源附近的广东省开始的。此外，我们在2013-2016年间从广东省蝙蝠收集的9.8％（591个中的58个）肛门拭子中鉴定出SADS相关冠状病毒，其序列同一性为96-98％，主要是在已知的马蹄蝠（Rhinolophus spp。）中SARS相关CoV的储存库。我们发现，在地理，时间，生态和病因环境中，SARS和SARS暴发之间有着惊人的相似性。这项研究强调了识别蝙蝠冠状病毒多样性和分布的重要性，以减轻可能威胁牲畜，公共卫生和经济增长的未来爆发。

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  • 来源
    《Nature》 |2018年第7700期|255-258|共4页
  • 作者

    Zhou Peng; Fan Hang; Lan Tian; Yang Xing-Lou; Shi Wei-Feng; Zhang Wei; Zhu Yan; Zhang Ya-Wei; Xie Qing-Mei; Mani Shailendra; Zheng Xiao-Shuang; Li Bei; Li Jin-Man; Guo Hua; Pei Guang-Qian; An Xiao-Ping; Chen Jun-Wei; Zhou Ling; Mai Kai-Jie; Wu Zi-Xian; Li Di; Anderson Danielle E.; Zhang Li-Biao; Li Shi-Yue; Mi Zhi-Qiang; He Tong-Tong; Cong Feng; Guo Peng-Ju; Huang Ren; Luo Yun; Liu Xiang-Ling; Chen Jing; Huang Yong; Sun Qiang; Zhang Xiang-Li-Lan; Wang Yuan-Yuan; Xing Shao-Zhen; Chen Yan-Shan; Sun Yuan; Li Juan; Daszak Peter; Wang Lin-Fa; Shi Zheng-Li; Tong Yi-Gang; Ma Jing-Yun;

  • 作者单位

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An, Shandong, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore;

    Guangdong Inst Appl Biol Resources, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangdong Key Lab Anim Conservat & Resource Util, Guangzhou, Guangdong, Peoples R China;

    Wuhan Univ, Sch Publ Hlth, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Guangdong Lab Anim Monitoring Inst, Guangdong Key Lab Lab Anim, Guangzhou, Guangdong, Peoples R China;

    Guangdong Lab Anim Monitoring Inst, Guangdong Key Lab Lab Anim, Guangzhou, Guangdong, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

    Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An, Shandong, Peoples R China;

    EcoHlth Alliance, New York, NY 10001 USA;

    Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore;

    Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China;

    Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China;

    South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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