New approaches for brain repair-from rescue to reprogramming

Barkers Roger A.; Goetz Magdalena; Parmar Malin

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New approaches for brain repair-from rescue to reprogramming

机译：大脑修复的新方法-从抢救到重新编程

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The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of, reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

机译：数十年来已经设想了修复或促进成人大脑内再生的能力。直到最近，这种努力主要涉及生长因子的递送和旨在抢救或替换特定神经元群体的细胞移植，其结果在很大程度上令人失望。使用干细胞衍生的细胞产物和直接细胞重编程的新方法为重建神经回路和实现更好的修复开辟了可能性。在这篇综述中，我们简要总结了神经修复的历史，然后讨论了这些新的治疗方法，尤其是关于慢性神经退行性疾病。

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《Nature》 |2018年第7705期|329-334|共6页
作者
Barkers Roger A.; Goetz Magdalena; Parmar Malin;
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作者单位

Univ Cambridge, Dept Clin Neurosci, Cambridge, England;

Ludwig Maximilians Univ Munchen, Biomed Ctr, Helmholtz Ctr Munich & Physiol Genom, Inst Stem Cell Res, Planegg Martinsried, Germany;

Lund Univ, Wallenberg Neurosci Ctr, Lund, Sweden;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. A small molecule Hedgehog agonist HhAg1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure [J] . Mitra Abhisek, Yan Jun, Zhang Liangfang, Translational research: the journal of laboratory and clinical medicine . 2019,第期

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2. Reprogramming the metabolome rescues retinal degeneration [J] . Park Karen Sophia, Xu Christine L., Cui Xuan, Cellular and molecular life sciences: CMLS . 2018,第9期

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机译：重编程细胞命运：组合方法的见解
5. Germany's Embrace of a Rescue Culture -- a Comparison Between the Approaches Taken in Germany, Canada and the United States. [D] . Ruenz, Sebastian Frederik. 2013

机译：德国对救援文化的拥抱-德国，加拿大和美国采取的方法之间的比较。
6. Focus: Induced Pluripotency Cellular Reprogramming: Probing disorders of the nervous system using reprogramming approaches [O] . Justin K Ichida, Evangelos Kiskinis 2015

机译：重点：诱导多能性和细胞重编程：使用重编程方法探查神经系统疾病
7. Direct Reprogramming of Human DMD Fibroblasts into Myotubes for In Vitro Evaluation of Antisense-Mediated Exon Skipping and Exons 45–55 Skipping Accompanied by Rescue of Dystrophin Expression [O] . Joshua J. A. Lee, Takashi Saito, William Duddy, 2018

机译：将人DMD成纤维细胞的直接重新编程成肌管，用于体外评估反义介导的外显子跳跃，外显子45-55跳跃伴有营养不良蛋白表达

New approaches for brain repair-from rescue to reprogramming

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