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Coherent encoding of subjective spatial position in visual cortex and hippocampus

机译：视觉皮层和海马体中主观空间位置的相干编码

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摘要

A major role of vision is to guide navigation, and navigation is strongly driven by vision(1-4). Indeed, the brain's visual and navigational systems are known to interact(5,6), and signals related to position in the environment have been suggested to appear as early as in the visual cortex(6,7). Here, to establish the nature of these signals, we recorded in the primary visual cortex (V1) and hippocampal area CA1 while mice traversed a corridor in virtual reality. The corridor contained identical visual landmarks in two positions, so that a purely visual neuron would respond similarly at those positions. Most V1 neurons, however, responded solely or more strongly to the landmarks in one position rather than the other. This modulation of visual responses by spatial location was not explained by factors such as running speed. To assess whether the modulation is related to navigational signals and to the animal's subjective estimate of position, we trained the mice to lick for a water reward upon reaching a reward zone in the corridor. Neuronal populations in both CA1 and V1 encoded the animal's position along the corridor, and the errors in their representations were correlated. Moreover, both representations reflected the animal's subjective estimate of position, inferred from the animal's licks, better than its actual position. When animals licked in a given location-whether correctly or incorrectly-neural populations in both V1 and CA1 placed the animal in the reward zone. We conclude that visual responses in V1 are controlled by navigational signals, which are coherent with those encoded in hippocampus and reflect the animal's subjective position. The presence of such navigational signals as early as a primary sensory area suggests that they permeate sensory processing in the cortex.
机译：视觉的主要作用是引导导航，导航是视觉的强烈驱动（1-4）。实际上，已知大脑的视觉和导航系统会相互作用（5,6），并且已建议与环境位置有关的信号最早出现在视觉皮层中（6,7）。在这里，为了确定这些信号的性质，我们在虚拟现实中小鼠穿越走廊时记录在主要视觉皮层（V1）和海马区CA1中。走廊在两个位置包含相同的视觉界标，因此，纯视觉神经元在这些位置的响应类似。但是，大多数V1神经元只对一个位置的地标产生反应，或者对另一位置的反应更为强烈。空间位置对视觉响应的这种调节没有通过运行速度等因素进行解释。为了评估调制是否与导航信号以及动物的位置主观估计有关，我们训练了小鼠在到达走廊的奖励区域时舔食水奖励。 CA1和V1中的神经元种群都对动物在走廊上的位置进行了编码，并且它们的表示中的错误也具有相关性。此外，从动物的舔s推断，这两种表示均反映出动物对位置的主观估计要好于其实际位置。当动物在给定位置舔食时-V1和CA1中的神经种群是否正确都将其置于奖励区中。我们得出结论，V1中的视觉反应受导航信号控制，该信号与海马编码的信号一致并反映了动物的主观位置。这种导航信号早在主要的感觉区域就已经存在，这表明它们渗透到了皮质的感觉过程中。

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  • 来源
    《Nature》 |2018年第7725期|124-127|共4页
  • 作者

    Saleem Aman B.; Diamanti E. Mika; Fournier Julien; Harris Kenneth D.; Carandini Matteo;

  • 作者单位

    UCL, UCL Inst Ophthalmol, London, England;

    UCL, UCL Inst Ophthalmol, London, England;

    UCL, UCL Inst Ophthalmol, London, England;

    UCL, UCL Inst Neurol, London, England;

    UCL, UCL Inst Ophthalmol, London, England;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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