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Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking

机译：伽马振荡组织自下而上的下丘脑信号传导，使寻找食物成为可能

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摘要

Both humans and animals seek primary rewards in the environment, even when such rewards do not correspond to current physiological needs. An example of this is a dissociation between food-seeking behaviour and metabolic needs, a notoriously difficult-to treat symptom of eating disorders. Feeding relies on distinct cell groups in the hypothalamus(1-4), the activity of which also changes in anticipation of feeding onset(5-7). The hypothalamus receives strong descending inputs from the lateral septum, which is connected, in turn, with cortical networks', but cognitive regulation of feeding-related behaviours is not yet understood. Cortical cognitive processing(9,10) involves gamma oscillations(11-15), which support memory(16,17), attention(18), cognitive flexibility(19) and sensory responses(20). These functions contribute crucially to feeding behaviour by unknown neural mechanisms. Here we show that coordinated gamma (30-90 Hz) oscillations in the lateral hypothalamus and upstream brain regions organize food seeking behaviour in mice. Gamma-rhythmic input to the lateral hypothalamus from somatostatin-positive lateral septum cells evokes food approach without affecting food intake. Inhibitory inputs from the lateral septum enable separate signalling by lateral hypothalamus neurons according to their feeding-related activity, making them fire at distinct phases of the gamma oscillation. Upstream, medial prefrontal cortical projections provide gamma rhythmic inputs to the lateral septum; these inputs are causally associated with improved performance in a food-rewarded learning task. Overall, our work identifies a top-down pathway that uses gamma synchronization to guide the activity of subcortical networks and to regulate feeding behaviour by dynamic reorganization of functional cell groups in the hypothalamus.
机译：人类和动物都寻求环境中的主要奖励，即使这种奖励与当前的生理需求不符。这方面的一个例子是寻求食物的行为与新陈代谢需求之间的分离，这是众所周知难以治疗的饮食失调症状。进食依赖于下丘脑中不同的细胞群（1-4），其活性也随着进食开始的预期而改变（5-7）。下丘脑从外侧中隔接收到强有力的降序输入，而后隔又与皮层网络相连，但对与进食相关行为的认知调节尚不了解。皮质认知处理（9,10）涉及伽玛振荡（11-15），可支持记忆（16,17），注意力（18），认知柔韧性（19）和感觉反应（20）。这些功能通过未知的神经机制对进食行为至关重要。在这里，我们显示了下丘脑外侧和上游大脑区域的协调伽马（30-90 Hz）振荡组织了小鼠的觅食行为。生长抑素阳性的侧中隔细胞向下丘脑外侧的γ有节律的输入唤起了食物进食而不影响食物摄入。来自外侧隔的抑制性输入使下丘脑外侧神经元根据其与进食相关的活动而发出单独的信号，从而使其在伽马振荡的不同阶段触发。上游，内侧前额叶皮质投影为外侧隔提供了伽马节律性输入。这些投入与因食物奖励的学习任务中提高的绩效有因果关系。总的来说，我们的工作确定了一种自上而下的途径，该途径使用伽马同步来指导皮层下网络的活动并通过下丘脑中功能细胞群的动态重组来调节进食行为。

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  • 来源
    《Nature》 |2017年第7640期|232-236|共5页
  • 作者

    Carus-Cadavieco Marta; Gorbati Maria; Ye Li; Bender Franziska; van der Veldt Suzanne; Kosse Christin; Borgers Christoph; Lee Soo Yeun; Ramakrishnan Charu; Hu Yubin; Denisova Natalia; Ramm Franziska; Volitaki Emmanouela; Burdakov Denis; Deisseroth Karl; Ponomarenko Alexey; Korotkova Tatiana;

  • 作者单位

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA|Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Francis Crick Inst, Mill Hill Lab, London NW7 1AA, England;

    Tufts Univ, Dept Math, Medford, MA 02155 USA;

    Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA;

    Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Francis Crick Inst, Mill Hill Lab, London NW7 1AA, England;

    Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA|Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA|Stanford Univ, Dept Psychiat & Behav Sci, W080 Clark Ctr,318 Campus Dr West, Stanford, CA 94305 USA;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

    Leibniz Inst Mol Pharmacol FMP, NeuroCure Cluster Excellence, Behav Neurodynam Grp, Berlin, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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