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Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

机译：前额叶皮层输出电路通过发散线索编码指导奖励寻找

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摘要

The prefrontal cortex is a critical neuroanatomical hub for controlling motivated behaviours across mammalian species(1-3). In addition to intra-cortical connectivity, prefrontal projection neurons innervate subcortical structures that contribute to reward-seeking behaviours, such as the ventral striatum and midline thalamus(4). While connectivity among these structures contributes to appetitive behaviours(5-13), how projection-specific prefrontal neurons encode reward-relevant information to guide reward seeking is unknown. Here we use in vivo two-photon calcium imaging to monitor the activity of dorsomedial prefrontal neurons in mice during an appetitive Pavlovian conditioning task. At the population level, these neurons display diverse activity patterns during the presentation of reward-predictive cues. However, recordings from prefrontal neurons with resolved projection targets reveal that individual corticostriatal neurons show response tuning to reward-predictive cues, such that excitatory cue responses are amplified across learning. By contrast, corticothalamic neurons gradually develop new, primarily inhibitory responses to reward-predictive cues across learning. Furthermore, bidirectional optogenetic manipulation of these neurons reveals that stimulation of corticostriatal neurons promotes conditioned reward-seeking behaviour after learning, while activity in corticothalamic neurons suppresses both the acquisition and expression of conditioned reward seeking. These data show how prefrontal circuitry can dynamically control rewardseeking behaviour through the opposing activities of projection-specific cell populations.
机译：前额叶皮层是控制跨哺乳动物物种的动机行为的关键神经解剖学枢纽（1-3）。除了皮层内的连通性外，前额叶投射神经元还影响皮层下的结构，这些结构有助于寻求奖励的行为，例如腹侧纹状体和中线丘脑（4）。虽然这些结构之间的连通性促进了竞争行为（5-13），但是投影特定的前额叶神经元如何编码与奖励相关的信息以指导寻求奖励的方法尚不清楚。在这里，我们使用体内的双光子钙成像来监测在一个有竞争性的巴甫洛夫式调理任务期间小鼠背背前额神经元的活动。在总体水平上，这些神经元在奖励预测提示的呈现过程中显示出不同的活动模式。但是，前额叶神经元的投射目标解析后的记录显示，单个皮质口神经元显示出对奖励预测线索的响应调整，从而在整个学习过程中会激发出兴奋性线索响应。相比之下，皮层丘脑神经元在整个学习过程中逐渐发展出对奖励预测线索的新的主要是抑制性反应。此外，这些神经元的双向光遗传学操作显示，皮质小脑神经元的刺激促进学习后的条件性奖励寻求行为，而皮质丘脑神经元的活动抑制条件性奖励寻求的获取和表达。这些数据表明前额叶电路如何通过特定于投影的细胞群体的相反活动动态地控制寻求奖励的行为。

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  • 来源
    《Nature》 |2017年第7643期|103-107|共5页
  • 作者

    Otis James M.; Namboodiri Vijay M. K.; Matan Ana M.; Voets Elisa S.; Mohorn Emily P.; Kosyk Oksana; McHenry Jenna A.; Robinson J. Elliott; Resendez Shanna L.; Rossi Mark A.; Stuber Garret D.;

  • 作者单位

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA|Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA|Univ N Carolina, Neurosci Curriculum, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA;

    Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA|Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA|Univ N Carolina, Neurosci Curriculum, Chapel Hill, NC 27599 USA|Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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