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Global translational reprogramming is a fundamental layer of immune regulation in plants

机译：全局翻译重编程是植物免疫调节的基础层

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摘要

In the absence of specialized immune cells, the need for plants to reprogram transcription to transition from growth-related activities to defence is well understood(1,2). However, little is known about translational changes that occur during immune induction. Using ribosome footprinting, here we perform global translatome profiling on Arabidopsis exposed to the microbe-associated molecular pattern elf18. We find that during this pattern-triggered immunity, translation is tightly regulated and poorly correlated with transcription. Identification of genes with altered translational efficiency leads to the discovery of novel regulators of this immune response. Further investigation of these genes shows that messenger RNA sequence features are major determinants of the observed translational efficiency changes. In the 5' leader sequences of transcripts with increased translational efficiency, we find a highly enriched messenger RNA consensus sequence, R-motif, consisting of mostly purines. We show that R-motif regulates translation in response to pattern-triggered immunity induction through interaction with poly(A)-binding proteins. Therefore, this study provides not only strong evidence, but also a molecular mechanism, for global translational reprogramming during pattern-triggered immunity in plants.
机译：在没有专门的免疫细胞的情况下，植物重新编程转录以使其从与生长相关的活性过渡到防御的需求已广为人知（1,2）。但是，对于免疫诱导过程中发生的翻译变化知之甚少。使用核糖体足迹，我们在暴露于微生物相关分子模式elf18的拟南芥上进行整体转录组分析。我们发现在这种模式触发的免疫过程中，翻译受到严格调节，并且与转录的相关性很差。鉴定具有改变的翻译效率的基因导致发现这种免疫应答的新型调节剂。这些基因的进一步研究表明，信使RNA序列特征是观察到的翻译效率变化的主要决定因素。在翻译效率提高的转录本的5'前导序列中，我们发现了高度富集的信使RNA共有序列R-motif，主要由嘌呤组成。我们表明R-基序调节翻译响应模式触发的免疫诱导通过与poly（A）结合蛋白的相互作用。因此，这项研究不仅为植物触发模式的免疫过程中的整体翻译重编程提供了强有力的证据，而且还提供了分子机制。

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  • 来源
    《Nature》 |2017年第7655期|487-490|共4页
  • 作者

    Xu Guoyong; Greene George H.; Yoo Heejin; Liu Lijing; Marques Jorge; Motley Jonathan; Dong Xinnian;

  • 作者单位

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

    Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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