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Blocking FSH induces thermogenic adipose tissue and reduces body fat

机译:阻止FSH诱导产热脂肪组织并减少体内脂肪

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摘要

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the beta-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the beta-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.
机译:更年期与骨质流失和内脏脂肪增多有关。靶向垂体激素促卵泡激素(Fsh)的β亚基的多克隆抗体会增加小鼠的骨量。在这里,我们报告该抗体急剧减少野生型小鼠的脂肪组织,表型复制Fsh受体基因Fshr的遗传单倍体不足。该抗体还引起深蓝色,增加细胞线粒体密度,激活褐色脂肪组织并增强生热作用。这些作用是由于抗体与Fsh的β亚基特异性结合所致,以阻断其作用。我们的研究发现了同时治疗肥胖症和骨质疏松症的机会。

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  • 来源
    《Nature》 |2017年第7656期|107-112|共6页
  • 作者单位

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA|Wuhan Univ, Sch & Hosp Stomatol, Wuhan 430079, Hubei, Peoples R China|Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA;

    Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA;

    Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA;

    Univ Colorado, Dept Obstet & Gynecol, Sch Med, Aurora, CO 80045 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Greater Los Angeles Vet Affairs Med Ctr, Pathol Serv, Los Angeles, CA 90073 USA;

    Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Rockefeller Univ, Prote Resource Ctr, New York, NY 10065 USA;

    Leiden Univ, Med Ctr, Dept Human Genet, NL-2311 EZ Leiden, Netherlands|Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, NL-2311 EZ Leiden, Netherlands;

    Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    UCL, Dept Pharmaceut & Biol Chem, Sch Pharm, London WC1N 1AX, England;

    Wuhan Univ, Sch & Hosp Stomatol, Wuhan 430079, Hubei, Peoples R China|Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA;

    Maine Med Ctr, Res Inst, Scarborough, ME 04074 USA;

    Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mt Sinai Bone Program, New York, NY 10029 USA|Wuhan Univ, Sch & Hosp Stomatol, Wuhan 430079, Hubei, Peoples R China|Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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