Less is more in the hunt for driver mutations

Kumar Sushant; Gerstein Mark

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Less is more in the hunt for driver mutations

机译：寻找驱动程序变异时，少即是多

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An analysis of 360 breast-cancer genomes has identified cancer-driving mutations in 9 non-coding DNA sequences called promoters, which regulate gene expression. The result hints at the prevalence of non-coding drivers. See Article p.55

机译：对360个乳腺癌基因组的分析确定了9个非编码DNA序列中的癌症驱动突变，这些DNA序列称为启动子，可调节基因表达。结果暗示了非编码驱动程序的普遍性。参见第55页

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来源
《Nature》 |2017年第7661期|40-41|共2页
作者
Kumar Sushant; Gerstein Mark;
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作者单位

Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA|Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA;

Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA|Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA|Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA;

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正文语种 eng
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2. Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression [J] . Piscuoglio Salvatore, Ng Charlotte K. Y., Murray Melissa, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2016,第4期

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3. Clinical Relevance of Driver Mutations and Number of Driver Mutations in Patients with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia [J] . Montalban-Bravo Guillermo, Takahashi Koichi, Wang Feng, Blood: The Journal of the American Society of Hematology . 2016,第22期

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4. PathMEx: Pathway-Based Mutual Exclusivity for Discovering Rare Cancer Driver Mutations [C] . Yahya Bokhari, Tomasz Arodz International Conference on Computational Science and Its Applications . 2021

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7. Less is more in the hunt for driver mutations [O] . Sushant Kumar, Mark Gerstein 2017

机译：少在寻找司机突变中的更多

Less is more in the hunt for driver mutations

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