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Pre-oral gut contributes to facial structures in non-teleost fishes

机译：口腔前肠道有助于非远鳍鱼类的面部结构

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摘要

Despite the wide variety of adaptive modifications in the oral and facial regions of vertebrates, their early oropharyngeal development is considered strictly uniform. It involves sequential formation of the mouth and pharyngeal pouches, with ectoderm outlining the outer surface and endoderm the inner surface, as a rule(1,2). At the extreme anterior domain of vertebrate embryos, the ectoderm and endoderm directly juxtapose and initial development of this earliest ecto-endoderm interface, the primary mouth(3), typically involves ectodermal stomodeal invagination that limits the anterior expansion of the foregut endoderm(3,4). Here we present evidence that in embryos of extant non-teleost fishes, oral (stomodeal) formation is preceded by the development of prominent pre-oral gut diverticula (POGD) between the forebrain and roof of the forming mouth. Micro-computed tomography (micro-CT) imaging of bichir, sturgeon and gar embryos revealed that foregut outpocketing at the pre-oral domain begins even before the sequential formation of pharyngeal pouches. The presence of foregut-derived cells in the front of the mouth was further confirmed by in vivo experiments that allowed specific tracing of the early endodermal lining. We show that POGD in sturgeons contribute to the orofacial surface of their larvae, comprising oral teeth, lips, and sensory barbels. To our knowledge, this is the first thorough evidence for endodermal origin of external craniofacial structures in any vertebrate. In bichir and gar embryos, POGD form prominent cranial adhesive organs that are characteristic of the ancient bauplan of free-living chordate larvae. POGD hence seem arguably to be ancestral for all ray-finned fishes, and their topology, pharyngeal-like morphogenesis and gene expression suggest that they are evolutionarily related to the foregut-derived diverticula of early chordate and hemichordate embryos. The formation of POGD might thus represent an ancestral developmental module with deep deuterostome origins.
机译：尽管脊椎动物的口腔和面部区域有各种各样的适应性修饰，但它们的早期口咽发育被认为是严格一致的。它通常依次形成口腔和咽囊，外胚层勾勒出外表面，内胚层勾勒出内表面（1,2）。在脊椎动物胚胎的最前部区域，外胚层和内胚层直接并列并最早发展出这种最早的外胚层-内胚层界面，主要是嘴巴（3），通常涉及外胚层的口腔内陷，限制了前肠内胚层的前向扩张（3， 4）。在这里，我们提供的证据表明，在现存的非远足鱼类的胚胎中，口腔（stomodeal）的形成是在前脑和成形嘴的顶部之间发育出显着的口腔前憩室（POGD）。比希尔，st鱼和鱼胚胎的微计算机断层扫描（micro-CT）成像显示，甚至在依次形成咽囊之前，前齿域的前肠扒窃就开始了。通过体内实验可以进一步证实早期内胚层衬里的存在，从而进一步证实了口前部存在前肠来源的细胞。我们显示st鱼中的POGD有助于其幼虫的口腔表面，包括牙齿，嘴唇和感觉性口须。据我们所知，这是任何脊椎动物外部颅面结构的内胚层起源的第一个全面证据。在比歇尔人和人的胚胎中，POGD形成了突出的颅骨黏附器官，这是古代自由活动的r酸盐幼虫包兰的特征。因此，POGD似乎可以说是所有射线鳍鱼类的祖先，并且它们的拓扑结构，咽样形态发生和基因表达表明它们在进化上与源自前肠的叉状和半胸状胚胎的憩室有关。因此，POGD的形成可能代表具有深氘口起源的祖先发育模块。

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  • 来源
    《Nature》 |2017年第7662期|209-212|共4页
  • 作者

    Minarik Martin; Stundl Jan; Fabian Peter; Jandzik David; Metscher Brian D.; Psenicka Martin; Gela David; Osorio-Perez Adriana; Arias-Rodriguez Lenin; Horacek Ivan; Cerny Robert;

  • 作者单位

    Charles Univ Prague, Dept Zool, Prague, Czech Republic;

    Charles Univ Prague, Dept Zool, Prague, Czech Republic|Natl Museum, Dept Zool, Prague, Czech Republic;

    Charles Univ Prague, Dept Zool, Prague, Czech Republic;

    Comenius Univ, Dept Zool, Bratislava, Slovakia;

    Univ Vienna, Dept Theoret Biol, Vienna, Austria;

    Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, Res Inst Fish Culture & Hydrobiol, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Vodnany, Austria;

    Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, Res Inst Fish Culture & Hydrobiol, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Vodnany, Austria;

    Univ Juarez Autonoma Tabasco, Div Acad Ciencias Biol, Villahermosa, Mexico;

    Univ Juarez Autonoma Tabasco, Div Acad Ciencias Biol, Villahermosa, Mexico;

    Charles Univ Prague, Dept Zool, Prague, Czech Republic;

    Charles Univ Prague, Dept Zool, Prague, Czech Republic;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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