Accounting for reciprocal host-microbiome interactions in experimental science

Stappenbeck Thaddeus S.; Virgin Herbert W.

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Accounting for reciprocal host-microbiome interactions in experimental science

机译：解释实验科学中互惠的宿主-微生物组相互作用

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Mammals are defined by their metagenome, a combination of host and microbiome genes. This knowledge presents opportunities to further basic biology with translation to human diseases. However, the now-documented influence of the metagenome on experimental results and the reproducibility of in vivo mammalian models present new challenges. Here we provide the scientific basis for calling on all investigators, editors and funding agencies to embrace changes that will enhance reproducible and interpretable experiments by accounting for metagenomic effects. Implementation of new reporting and experimental design principles will improve experimental work, speed discovery and translation, and properly use substantial investments in biomedical research.

机译：哺乳动物由它们的基因组，宿主基因组和微生物组基因的组合定义。这些知识为进一步转化为人类疾病的基础生物学提供了机会。但是，现在已证明的元基因组对实验结果的影响以及体内哺乳动物模型的可再现性提出了新的挑战。在这里，我们提供了科学依据，呼吁所有研究人员，编辑和资助机构采用能够通过考虑宏基因组学效应来增强可重复性和可解释性实验的变化。新报告和实验设计原则的实施将改善实验工作，加快发现和翻译的速度，并适当地在生物医学研究中使用大量投资。

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来源
《Nature》 |2016年第7606期|191-199|共9页
作者
Stappenbeck Thaddeus S.; Virgin Herbert W.;
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Washington Univ, Sch Med, Dept Pathol & Immunol, Campus Box 8118,660 South Euclid Ave, St Louis, MO 63110 USA;

Washington Univ, Sch Med, Dept Pathol & Immunol, Campus Box 8118,660 South Euclid Ave, St Louis, MO 63110 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Accounting for reciprocal host-microbiome interactions in experimental science

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