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Transfer of mitochondria from astrocytes to neurons after stroke

机译：脑卒中后线粒体从星形胶质细胞转移到神经元

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摘要

Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling(1). This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system. Here we show that astrocytes in mice can also release functional mitochondria that enter neurons. Astrocytic release of extracellular mitochondrial particles was mediated by a calcium-dependent mechanism involving CD38 and cyclic ADP ribose signalling. Transient focal cerebral ischaemia in mice induced entry of astrocytic mitochondria into adjacent neurons, and this entry amplified cell survival signals. Suppression of CD38 signalling by short interfering RNA reduced extracellular mitochondria transfer and worsened neurological outcomes. These findings suggest a new mitochondrial mechanism of neuroglial crosstalk that may contribute to endogenous neuroprotective and neurorecovery mechanisms after stroke.
机译：神经元可以释放受损的线粒体，并将其转移至星形胶质细胞进行处置和回收利用（1）。交换线粒体的这种能力可能代表中枢神经系统中细胞间信号传导的潜在模式。在这里，我们显示了小鼠中的星形胶质细胞还可以释放进入神经元的功能性线粒体。细胞外线粒体颗粒的星形细胞释放是由涉及CD38和环状ADP核糖信号传导的钙依赖性机制介导的。小鼠短暂性局灶性脑缺血诱导星形细胞线粒体进入相邻神经元，这种进入放大了细胞存活信号。短干扰RNA抑制CD38信号传导减少了细胞外线粒体的转移，并恶化了神经系统的预后。这些发现提示神经胶质串扰的一种新的线粒体机制，可能有助于中风后的内源性神经保护和神经恢复机制。

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  • 来源
    《Nature》 |2016年第7613期|551-555|共5页
  • 作者

    Hayakawa Kazuhide; Esposito Elga; Wang Xiaohua; Terasaki Yasukazu; Liu Yi; Xing Changhong; Ji Xunming; Lo Eng H.;

  • 作者单位

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA|Capital Med Univ, Xuanwu Hosp, Cerebrovasc Res Ctr, Beijing 100053, Peoples R China;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA|Capital Med Univ, Xuanwu Hosp, Cerebrovasc Res Ctr, Beijing 100053, Peoples R China;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA;

    Capital Med Univ, Xuanwu Hosp, Cerebrovasc Res Ctr, Beijing 100053, Peoples R China;

    Massachusetts Gen Hosp, Dept Radiol, Neuroprotect Res Lab, Charlestown, MA 02129 USA|Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA|Harvard Med Sch, Charlestown, MA 02129 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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