The ecology of the gut microbiome may trigger or contribute to a variety of diseases, including autoimmune disorders and obesity, research suggests. Factors such as early environment, diet and antibiotic exposure have a lot to do with why people differ from one another in the composition of their microbiomes. But specific gene variants are also linked to greater risks of developing many of these diseases. Do your genes act on your microbiome, which in turn promotes disease? One way researchers have addressed this question is to pick specific genes that are good candidates-for instance, those with a strong link to a disease that also has a microbiome link-and examine whether people who carry mutations that are known to increase the risk of a certain disease also have microbiomes that differ from those who do not have the mutations. A team led by Dan Frank at the University of Colorado Denver took this approach and revealed that specific variants of the NOD2 gene that confer a high risk of developing inflammatory bowel disease to their carriers are also associated with an altered intestinal microbiome.
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机译：6.一种化合物，其包含具有根据20的EP-B1-2563920（SEQ ID NO：80）的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸，其中所述修饰的寡核苷酸包含：由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间，其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶，并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物，例如由EP-B1-2563920保护的其盐，包括钠盐。
