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A motor cortex circuit for motor planning and movement

机译：用于运动计划和运动的运动皮质电路

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摘要

在很多物种中，运动开始之前都发现运动皮层和运动前皮层中的神经活动增加。这种活动对于将要发生的运动的方向来说往往不是特定的，它与运动信号有什么关系仍不清楚。在这项研究中，Karel Svoboda及同事分析了小鼠前侧向运动皮层内的神经元对运动规划的贡献。他们发现了具有相应于其各自功能反应的不同连接的不同神经元类群:投射到下游区域的神经元类群比投射到其他皮层目标的神经元类群对于将要发生的运动的方向更有选择性。这些结果突显了在行为过程中测出的复杂神经反应需要怎样按照它们所参与的神经回路的组织方式来加以解读。%Activity in motor cortex predicts specific movements seconds before they occur, but how this preparatory activity relates to upcoming movements is obscure. We dissected the conversion of preparatory activity to movement within a structured motor cortex circuit. An anterior lateral region of the mouse cortex (a possible homologue of premotor cortex in primates) contains equal proportions of intermingled neurons predicting ipsi- or contralateral movements, yet unilateral inactivation of this cortical region during movement planning disrupts contralateral movements. Using cell-type-specific electrophysiology, cellular imaging and optogenetic perturbation, we show that layer 5 neurons projecting within the cortex have unbiased laterality. Activity with a contralateral population bias arises specifically in layer 5 neurons projecting to the brainstem, and only late during movement planning. These results reveal the transformation of distributed preparatory activity into movement commands within hierarchically organized cortical circuits.
机译：在很多物种中，运动开始之前都发现运动皮层和运动前皮层中的神经活动增加。这种活动对于将要发生的运动的方向来说往往不是特定的，它与运动信号有什么关系仍不清楚。在这项研究中，Karel Svoboda及同事分析了小鼠前侧向运动皮层内的神经元对运动规划的贡献。他们发现了具有相应于其各自功能反应的不同连接的不同神经元类群:投射到下游区域的神经元类群比投射到其他皮层目标的神经元类群对于将要发生的运动的方向更有选择性。这些结果突显了在行为过程中测出的复杂神经反应需要怎样按照它们所参与的神经回路的组织方式来加以解读。%Activity in motor cortex predicts specific movements seconds before they occur, but how this preparatory activity relates to upcoming movements is obscure. We dissected the conversion of preparatory activity to movement within a structured motor cortex circuit. An anterior lateral region of the mouse cortex (a possible homologue of premotor cortex in primates) contains equal proportions of intermingled neurons predicting ipsi- or contralateral movements, yet unilateral inactivation of this cortical region during movement planning disrupts contralateral movements. Using cell-type-specific electrophysiology, cellular imaging and optogenetic perturbation, we show that layer 5 neurons projecting within the cortex have unbiased laterality. Activity with a contralateral population bias arises specifically in layer 5 neurons projecting to the brainstem, and only late during movement planning. These results reveal the transformation of distributed preparatory activity into movement commands within hierarchically organized cortical circuits.

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  • 来源
    《Nature》 |2015年第7541期|51-56A1|共7页
  • 作者

    Nuo Li; Tsai-Wen Chen; Zengcai V. Guo; Charles R. Gerfen; Karel Svoboda;

  • 作者单位

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA;

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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