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Thermosensory processing in the Drosophila brain

机译：果蝇大脑中的热感处理

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摘要

动物通过周围神经系统中的热感受器来检测外部温度的变化，但随后处理这种信号的中央回路此前却一直不知道。现在，由Rachel Wilson和Marco Gallio领导完成的两项研究课题报告了果蝇脑中两个截然不同的神经元类别，它们对外部变冷、变暖或同时对变冷和变暖做出反应，并对行为反应做出贡献。这些结果显示了高等脑中心是怎样从周围神经系统中一个简单的温度图来提取某一刺激的质量、强度和时间信息的。%In Drosophila, just as in vertebrates, changes in external temperature are encoded by bidirectional opponent thermoreceptor cells: some cells are excited by warming and inhibited by cooling, whereas others are excited by cooling and inhibited by warming. The central circuits that process these signals are not understood. In Drosophila, a specific brain region receives input from thermoreceptor cells. Here we show that distinct genetically identified projection neurons (PNs) in this brain region are excited by cooling, warming, or both. The PNs excited by cooling receive mainly feed-forward excitation from cool thermoreceptors. In contrast, the PNs excited by warming ('warm-PNs') receive both excitation from warm thermoreceptors and crossover inhibition from cool thermoreceptors through inhibitory interneurons. Notably, this crossover inhibition elicits warming-evoked excitation, because warming suppresses tonic activity in cool thermoreceptors. This in turn disinhibits warm-PNs and sums with feed-forward excitation evoked by warming. Crossover inhibition could cancel non-thermal activity (noise) that is positively correlated among warm and cool thermoreceptor cells, while reinforcing thermal activity which is anti-correlated. Our results show how central circuits can combine signals from bidirectional opponent neurons to construct sensitive and robust neural codes.
机译：动物通过周围神经系统中的热感受器来检测外部温度的变化，但随后处理这种信号的中央回路此前却一直不知道。现在，由Rachel Wilson和Marco Gallio领导完成的两项研究课题报告了果蝇脑中两个截然不同的神经元类别，它们对外部变冷、变暖或同时对变冷和变暖做出反应，并对行为反应做出贡献。这些结果显示了高等脑中心是怎样从周围神经系统中一个简单的温度图来提取某一刺激的质量、强度和时间信息的。%In Drosophila, just as in vertebrates, changes in external temperature are encoded by bidirectional opponent thermoreceptor cells: some cells are excited by warming and inhibited by cooling, whereas others are excited by cooling and inhibited by warming. The central circuits that process these signals are not understood. In Drosophila, a specific brain region receives input from thermoreceptor cells. Here we show that distinct genetically identified projection neurons (PNs) in this brain region are excited by cooling, warming, or both. The PNs excited by cooling receive mainly feed-forward excitation from cool thermoreceptors. In contrast, the PNs excited by warming ('warm-PNs') receive both excitation from warm thermoreceptors and crossover inhibition from cool thermoreceptors through inhibitory interneurons. Notably, this crossover inhibition elicits warming-evoked excitation, because warming suppresses tonic activity in cool thermoreceptors. This in turn disinhibits warm-PNs and sums with feed-forward excitation evoked by warming. Crossover inhibition could cancel non-thermal activity (noise) that is positively correlated among warm and cool thermoreceptor cells, while reinforcing thermal activity which is anti-correlated. Our results show how central circuits can combine signals from bidirectional opponent neurons to construct sensitive and robust neural codes.

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  • 来源
    《Nature》 |2015年第7543期|353-357A1|共6页
  • 作者

    Wendy W. Liu; Ofer Mazor; Rachel I. Wilson;

  • 作者单位

    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA;

    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA,Harvard NeuroDiscovery Center, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA;

    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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