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Thirst driving and suppressing signals encoded by distinct neural populations in the brain

机译:渴求驱动和抑制大脑中不同神经群编码的信号

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摘要

Thirst is the basic instinct to drink water. Previously, it was shown that neurons in several circumventricular organs of the hypothalamus are activated by thirst-inducing conditions. Here we identify two distinct, genetically separable neural populations in the subfornical organ that trigger or suppress thirst. We show that optogenetic activation of subfornical organ excitatory neurons, marked by the expression of the transcription factor ETV-1, evokes intense drinking behaviour, and does so even in fully water-satiated animals. The light-induced response is highly specific for water, immediate and strictly locked to the laser stimulus. In contrast, activation of a second population of subfornical organ neurons, marked by expression of the vesicular GAB A transporter VGAT, drastically suppresses drinking, even in water-craving thirsty animals. These results reveal an innate brain circuit that can turn an animaTs water-drinking behaviour on and off, and probably functions as a centre for thirst control in the mammalian brain.
机译:口渴是喝水的基本本能。以前,已证明下丘脑的几个室室器官中的神经元被诱导口渴的条件激活。在这里,我们确定了在子下器官中触发或抑制口渴的两个不同的,遗传上可分离的神经种群。我们表明,以转录因子ETV-1的表达为标志的子生殖器官兴奋性神经元的光遗传学激活会引起强烈的饮酒行为,甚至在完全饮水的动物中也是如此。光诱导的响应对水具有高度特异性,立即并严格锁定在激光刺激下。相比之下,以囊泡GAB A转运蛋白VGAT的表达为标志的第二亚器官器官下神经元的激活,即使在渴望水的口渴动物中,也能显着抑制饮酒。这些结果揭示了一种先天性大脑回路,该回路可以开启和关闭动物的饮水行为,并且可能充当哺乳动物大脑中口渴控制的中心。

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  • 来源
    《Nature》 |2015年第7547期|349-352|共4页
  • 作者单位

    Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA,Department of Neuroscience, Columbia College of Physiciansand Surgeons, Howard Hughes Medical Institute, Columbia University, NewYork, NewYork 10032, USA,Division of Biology and Biological Engineering 216-76, California Institute of Technology, Pasadena, California 91125, USA;

    Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA,Department of Neuroscience, Columbia College of Physiciansand Surgeons, Howard Hughes Medical Institute, Columbia University, NewYork, NewYork 10032, USA;

    Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA,Department of Neuroscience, Columbia College of Physiciansand Surgeons, Howard Hughes Medical Institute, Columbia University, NewYork, NewYork 10032, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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