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Oxytocin enables maternal behaviour by balancing cortical inhibition

机译：催产素通过平衡皮层抑制来促进孕产妇行为

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摘要

Oxytocin is important for social interactions and maternal behaviour. However, little is known about when, where and how oxytocin modulates neural circuits to improve social cognition. Here we show how oxytocin enables pup retrieval behaviour in female mice by enhancing auditory cortical pup call responses. Retrieval behaviour required the left but not right auditory cortex, was accelerated by oxytocin in the left auditory cortex, and oxytocin receptors were preferentially expressed in the left auditory cortex. Neural responses to pup calls were lateralized, with co-tuned and temporally precise excitatory and inhibitory responses in the left cortex of maternal but not pup-naive adults. Finally, pairing calls with oxytocin enhanced responses by balancing the magnitude and timing of inhibition with excitation. Our results describe fundamental synaptic mechanisms by which oxytocin increases the salience of acoustic social stimuli. Furthermore, oxytocin-induced plasticity provides a biological basis for lateralization of auditory cortical processing.
机译：催产素对于社交互动和孕产妇行为很重要。然而，关于催产素何时，何地以及如何调节神经回路以提高社交认知知之甚少。在这里，我们展示了催产素如何通过增强听觉皮层幼犬叫声应答来使雌性小鼠中的幼犬恢复行为。检索行为需要左但不是右听皮层，由左听皮层中的催产素加速，并且催产素受体优先在左听皮层中表达。对成年幼崽的神经反应被侧向化，在成年但未成年幼崽的成年人的左皮质中，发生了同步且在时间上精确的兴奋性和抑制性反应。最后，与催产素配对的呼叫通过平衡抑制与激发的幅度和时间来增强反应。我们的结果描述了基本的突触机制，催产素可通过这些突触机制提高听觉社交刺激的显着性。此外，催产素诱导的可塑性为听觉皮层处理的侧向化提供了生物学基础。

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  • 来源
    《Nature》 |2015年第7548期|499-504|共6页
  • 作者

    Marlin Bianca J.; Mitre Mariela; Damour James A.; Chao Moses V.; Froemke Robert C.;

  • 作者单位

    NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA|NYU, Sch Med, Neurosci Inst, New York, NY 10016 USA|NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA|NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA;

    NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA|NYU, Sch Med, Neurosci Inst, New York, NY 10016 USA|NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA|NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA|NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA|NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA;

    NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA|NYU, Sch Med, Neurosci Inst, New York, NY 10016 USA|NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA|NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA;

    NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA|NYU, Sch Med, Neurosci Inst, New York, NY 10016 USA|NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA|NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA|NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA|NYU, Ctr Neural Sci, New York, NY 10003 USA;

    NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA|NYU, Sch Med, Neurosci Inst, New York, NY 10016 USA|NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA|NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA|NYU, Ctr Neural Sci, New York, NY 10003 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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