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An alternative pluripotent state confers interspecies chimaeric competency

机译：另一个多能的国家赋予种间嵌合能力

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摘要

Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.
机译：多能性是产生人体任何细胞类型的能力，是胚胎细胞的e逝属性。暂时性多能细胞可在胚胎发生过程中的不同时间点捕获，并在培养中保持为胚胎干细胞或表皮干细胞。由于本体发生是时空的动态过程，因此这两个时间状态代表了生物多能性的整个谱，这似乎是违反直觉的。在这里我们表明，通过调节培养参数，可以有效地从小鼠胚胎和灵长类动物多能干细胞中获得具有独特空间特征以及独特的分子和功能特征的干细胞类型，称为区域选择性多能干细胞（rsPSC），包括人类。培养和编辑人rsPSC基因组的简便性为再生医学应用提供了优势。人类rsPSC产生植入后种间嵌合胚胎的独特能力可能有助于我们对人类早期发育和进化的理解。

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  • 来源
    《Nature》 |2015年第7552期|316-321|共6页
  • 作者

    Wu Jun; Okamura Daiji; Li Mo; Suzuki Keiichiro; Luo Chongyuan; Ma Li; He Yupeng; Li Zhongwei; Benner Chris; Tamura Isao; Krause Marie N.; Nery Joseph R.; Du Tingting; Zhang Zhuzhu; Hishida Tomoaki; Takahashi Yuta; Aizawa Emi; Kim Na Young; Lajara Jeronimo; Guillen Pedro; Campistol Josep M.; Esteban Concepcion Rodriguez; Ross Pablo J.; Saghatelian Alan; Ren Bing; Ecker Joseph R.; Belmonte Juan Carlos Izpisua;

  • 作者单位

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA|Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Integrated Genom, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA;

    Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, Dept Cellular & Mol Med, La Jolla, CA 92093 USA;

    Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA|Univ Tsukuba, Tsukuba Adv Res Alliance, Life Sci Ctr, Tsukuba, Ibaraki 3058577, Japan;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Univ Catolica, Med, Guadalupe 30107, Spain;

    Univ Catolica, Med, Guadalupe 30107, Spain|Fdn Pedro Guillen, Clin Cemtro, Madrid 28035, Spain;

    Hosp Clin Barcelona, E-08036 Barcelona, Spain;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

    Univ Calif Davis, Davis, CA 95616 USA;

    Salk Inst Biol Studies, Peptide Biol Lab, La Jolla, CA 92037 USA;

    Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, Dept Cellular & Mol Med, La Jolla, CA 92093 USA;

    Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA|Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA;

    Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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