Metabolic co-dependence gives rise to collective oscillations within biofilms

Liu Jintao; Prindle Arthur; Humphries Jacqueline; Gabalda-Sagarra Marcal; Asally Munehiro; Lee Dong-Yeon D.; Ly San; Garcia-Ojalvo Jordi; Sueel Guerol M.

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Metabolic co-dependence gives rise to collective oscillations within biofilms

机译：代谢共依赖性引起生物膜内的集体振荡

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Cells that reside within a community can cooperate and also compete with each other for resources. It remains unclear how these opposing interactions are resolved at the population level. Here we investigate such an internal conflict within a microbial (Bacillus subtilis) biofilm community: cells in the biofilm periphery not only protect interior cells from external attack but also starve them through nutrient consumption. We discover that this conflict between protection and starvation is resolved through emergence of long-range metabolic co-dependence between peripheral and interior cells. As a result, biofilm growth halts periodically, increasing nutrient availability for the sheltered interior cells. We show that this collective oscillation in biofilm growth benefits the community in the event of a chemical attack. These findings indicate that oscillations support population-level conflict resolution by coordinating competing metabolic demands in space and time, suggesting new strategies to control biofilm growth.

机译：居住在社区中的单元可以合作，也可以相互竞争资源。尚不清楚如何在人口一级解决这些对立的相互作用。在这里，我们调查了微生物（枯草芽孢杆菌）生物膜群落内部的这种内部冲突：生物膜外围的细胞不仅保护内部细胞免受外部攻击，而且由于营养消耗而使它们饥饿。我们发现，保护和饥饿之间的这种冲突是通过周围和内部细胞之间长距离代谢共依赖性的出现而解决的。结果，生物被膜的生长周期性地停止，从而增加了被遮盖的内部细胞的养分利用率。我们表明，如果发生化学攻击，生物膜生长的这种集体振荡将使社区受益。这些发现表明，振荡通过协调时空上相互竞争的新陈代谢需求来支持种群水平的冲突解决，从而提出了控制生物膜生长的新策略。

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《Nature》 |2015年第7562期|550-554|共5页
作者
Liu Jintao; Prindle Arthur; Humphries Jacqueline; Gabalda-Sagarra Marcal; Asally Munehiro; Lee Dong-Yeon D.; Ly San; Garcia-Ojalvo Jordi; Sueel Guerol M.;
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作者单位

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain;

Univ Warwick, Sch Life Sci, Warwick Integrat Synthet Biol Ctr, Coventry CV4 7AL, W Midlands, England|Univ Warwick, Sch Life Sci, Warwick Integrat Synthet Biol Ctr, Coventry CV4 7AL, W Midlands, England;

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain;

Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Differential equation-based minimal model describing metabolic oscillations in Bacillus subtilis biofilms [J] . Ravindra Garde, Bashar Ibrahim, ákos T. Kovács, Royal Society Open Science . 2020,第2期

机译：基于微分方式的最小模型，描述了枯草芽孢杆菌生物膜中的代谢振荡
2. Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis [J] . Mayuko Hamada, Katja Schr?der, Jay Bathia, eLife journal . 2018,第december期

机译：代谢的相互依赖性驱动了进化上古老的九头蛇-小球藻共生
3. Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis [J] . Mayuko Hamada, Katja Schr?der, Jay Bathia, eLife journal . 2018,第may期

机译：代谢的相互依赖性驱动了进化上古老的九头蛇-小球藻共生
4. Modeling the mechanism of metabolic oscillations in metabolically deprived cardiac myocytes [C] . Kotulska M., Jafi M.S. Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint . 2002

机译：对代谢缺乏的心肌细胞中代谢振荡的机制进行建模
5. Development and use of microelectrodes to evaluate nitrification within chloraminated drinking water system biofilms, and the effects of phosphate as a corrosion inhibitor on nitrifying biofilm. [D] . Lee, Woo Hyoung. 2009

机译：开发和使用微电极评估氯化饮用水系统生物膜中的硝化作用，以及磷酸盐作为腐蚀抑制剂对生物膜硝化的影响。
6. Metabolic codependence gives rise to collective oscillations within biofilms [O] . Jintao Liu, Arthur Prindle, Jacqueline Humphries, -1

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7. Metabolic co-dependence gives rise to collective oscillations within biofilms [O] . Liu, Jintao, Prindle, Arthur, Humphries, Jacqueline, 2015

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8. Method for Localizing and Differentiating Bacteria within Biofilms Grown on Indium Tin Oxide: Spatial Distribution of Exoelectrogenic Bacteria within Intact ITO Biofilms via FISH. [R] . Arnett, C. M., Lange, J. D. 2017

机译：在氧化铟锡生长的生物膜内定位和区分细菌的方法：通过FIsH在完整的ITO生物膜中的外电生物细菌的空间分布。

Metabolic co-dependence gives rise to collective oscillations within biofilms

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