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Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

机译：塞拉利昂埃博拉病毒的遗传多样性和进化动力学

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摘要

A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths(1,2). Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir(3) followed by sustained human-to-human infections(4). It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics(5,6). However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase(7). Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23x10(-3) substitutions per site per year (95% highest posterior density interval, 1.04x10(-3) to 1.41x10(-3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics.
机译：2014年3月首次发现的新型埃博拉病毒（EBOV）已感染西非25,000多人，导致10,000多人死亡（1,2）。对几内亚和塞拉利昂2014年3月至6月收集的81个EBOV基因组序列的初步分析表明，2014 EBOV源自其天然水库的一次独立传播事件（3），然后是持续的人对人感染（4）。据报道，EBOV基因组变异可能会影响基于序列的病毒检测和候选疗法的疗效（5,6）。但是，自2014年7月暴发进入快速增长阶段以来，只有很少的病毒信息可用（7）。在这里，我们描述了2014年9月28日至11月11日来自塞拉利昂五个严重灾区的175条全长EBOV基因组序列。我们发现，2014年EBOV从2014年7月至11月在系统发育和遗传上更加多样化。多个新世系。 2014年EBOV的替代率估计为每个站点每年1.23x10（-3）个替代（最高后验密度区间为95％，每个站点每年1.04x10（-3）至1.41x10（-3）替代），近似于以前的EBOV爆发之间观察到的情况。 2014年EBOV的遗传多样性急剧增加，因此有必要在塞拉利昂，几内亚和利比里亚进行广泛的EBOV监测，以更好地了解持续爆发的病毒进化和传播动态。这些数据将促进国际上开发疫苗和治疗剂的努力。

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  • 来源
    《Nature》 |2015年第7563期|93-96|共4页
  • 作者

    Tong Yi-Gang; Shi Wei-Feng; Liu Di; Qian Jun; Liang Long; Bo Xiao-Chen; Liu Jun; Ren Hong-Guang; Fan Hang; Ni Ming; Sun Yang; Jin Yuan; Teng Yue; Li Zhen; Kargbo David; Dafae Foday; Kanu Alex; Chen Cheng-Chao; Lan Zhi-Heng; Jiang Hui; Luo Yang; Lu Hui-Jun; Zhang Xiao-Guang; Yang Fan; Hu Yi; Cao Yu-Xi; Deng Yong-Qiang; Su Hao-Xiang; Sun Yu; Liu Wen-Sen; Wang Zhuang; Wang Cheng-Yu; Bu Zhao-Yang; Guo Zhen-Dong; Zhang Liu-Bo; Nie Wei-Min; Bai Chang-Qing; Sun Chun-Hua; An Xiao-Ping; Xu Pei-Song; Zhang Xiang-Li-Lan; Huang Yong; Mi Zhi-Qiang; Yu Dong; Yao Hong-Wu; Feng Yong; Xia Zhi-Ping; Zheng Xue-Xing; Yang Song-Tao; Lu Bing; Jiang Jia-Fu; Kargbo Brima; He Fu-Chu; Gao George F.; Cao Wu-Chun;

  • 作者单位

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Taishan Med Coll, Inst Pathogen Biol, Tai An 271000, Shandong, Peoples R China;

    Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Beijing Key Lab New Mol Diagnost Technol, Beijing 100850, Peoples R China;

    Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Beijing Key Lab New Mol Diagnost Technol, Beijing 100850, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Beijing Key Lab New Mol Diagnost Technol, Beijing 100850, Peoples R China;

    Sierra Leone Minist Hlth & Sanitat, Freetown, Sierra Leone;

    Sierra Leone Minist Hlth & Sanitat, Freetown, Sierra Leone;

    Sierra Leone China Friendship Hosp, Freetown, Sierra Leone;

    BGI Shenzhen, Shenzhen 518083, Peoples R China;

    BGI Shenzhen, Shenzhen 518083, Peoples R China;

    BGI Shenzhen, Shenzhen 518083, Peoples R China;

    Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China;

    Chinese Acad Med Sci, Beijing 100730, Peoples R China|Peking Union Med Coll, Beijing 100730, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Chinese Acad Med Sci, Beijing 100730, Peoples R China|Peking Union Med Coll, Beijing 100730, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safet, Beijing 100021, Peoples R China;

    302 Hosp, Beijing 100039, Peoples R China;

    307 Hosp, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Beijing Key Lab New Mol Diagnost Technol, Beijing 100850, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Natl Hlth & Family Planning Commiss, Dept Int Cooperat, Beijing 100044, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

    Sierra Leone Minist Hlth & Sanitat, Freetown, Sierra Leone;

    State Key Lab Prote, Beijing 102206, Peoples R China;

    Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China|Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China|Chinese Ctr Dis Control & Prevent, Beijing 102206, Peoples R China;

    State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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