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An early modern human from Romania with a recent Neanderthal ancestor

机译：来自罗马尼亚的早期现代人，最近的尼安德特人祖先

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摘要

Neanderthals are thought to have disappeared in Europe approximately 39,000-41,000 years ago but they have contributed 1-3% of the DNA of present-day people in Eurasia(1). Here we analyse DNA from a 37,000-42,000-year-old(2) modern human from Pestera cu Oase, Romania. Although the specimen contains small amounts of human DNA, we use an enrichment strategy to isolate sites that are informative about its relationship to Neanderthals and present-day humans. We find that on the order of 6-9% of the genome of the Oase individual is derived from Neanderthals, more than any other modern human sequenced to date. Three chromosomal segments of Neanderthal ancestry are over 50 centimorgans in size, indicating that this individual had a Neanderthal ancestor as recently as four to six generations back. However, the Oase individual does not share more alleles with later Europeans than with East Asians, suggesting that the Oase population did not contribute substantially to later humans in Europe.
机译：人们认为尼安德特人在欧洲大约39,000-41,000年前就已经消失了，但它们为欧亚大陆当今人们的DNA贡献了1-3％（1）。在这里，我们分析了来自罗马尼亚Pestera cu Oase的37,000-42,000岁（2）现代人的DNA。尽管标本中含有少量的人类DNA，但我们还是采用了富集策略来分离出一些有关其与尼安德特人和当今人类之间关系的信息。我们发现，Oase个人基因组的大约6-9％来自尼安德特人，比迄今测序的任何其他现代人类都多。尼安德特人祖先的三个染色体片段的大小超过50厘摩，这表明该人的尼安德特人祖先距今已有四到六代。但是，与东亚人相比，绿洲人与后来的欧洲人共享的等位基因并不多，这表明绿洲人对欧洲的后来世人没有实质性的贡献。

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  • 来源
    《Nature》 |2015年第7564期|216-219|共4页
  • 作者

    Fu Qiaomei; Hajdinjak Mateja; Moldovan Oana Teodora; Constantin Silviu; Mallick Swapan; Skoglund Pontus; Patterson Nick; Rohland Nadin; Lazaridis Iosif; Nickel Birgit; Viola Bence; Pruefer Kay; Meyer Matthias; Kelso Janet; Reich David; Paeaebo Svante;

  • 作者单位

    Chinese Acad Sci, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China|Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA|Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Emil Racovita Inst Speleol, Cluj Branch, Cluj Napoca 400006, Romania;

    Emil Racovita Inst Speleol, Dept Geospeleol & Paleontol, Bucharest 010986 12, Romania;

    Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Cambridge, MA 02142 USA|Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany;

    Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA;

    Broad Inst MIT & Harvard, Cambridge, MA 02142 USA;

    Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA;

    Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany|Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany|Univ Toronto, Dept Anthropol, Toronto, ON M5S 2S2, Canada;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

    Harvard Univ, Dept Genet, Sch Med, Boston, MA 02115 USA|Broad Inst MIT & Harvard, Cambridge, MA 02142 USA|Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA USA;

    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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