Hedgehog actively maintains adult lung quiescence and regulates repairn   and regeneration

Peng Tien; Frank David B.; Kadzik Rachel S.; Morley Michael P.; Rathi Komal S.; Wang Tao; Zhou Su; Cheng Lan; Lu Min Min; Morrisey Edward E.

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Hedgehog actively maintains adult lung quiescence and regulates repairn and regeneration

机译：刺猬积极维持成人肺部静止并调节修复和再生

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Postnatal tissue quiescence is thought to be a default state in the absence of a proliferative stimulus such as injury. Although previous studies have demonstrated that certain embryonic developmental programs are reactivated aberrantly in adult organs to drive repair and regeneration(1-3), it is not well understood how quiescence is maintained in organs such as the lung, which displays a remarkably low level of cellular turnover(4,5). Here we demonstrate that quiescence in the adult lung is an

机译：出生后的组织静止被认为是缺乏诸如损伤之类的增生刺激的默认状态。尽管先前的研究表明某些胚胎发育程序会在成年器官中异常激活以驱动修复和再生（1-3），但人们对如何在器官（例如肺）中保持静止状态的了解还不是很清楚，后者显示出非常低的胚胎发育水平。细胞周转率（4,5）。在这里，我们证明成年肺的静止是

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来源
《Nature》 |2015年第7574期|578-582|共5页
作者
Peng Tien; Frank David B.; Kadzik Rachel S.; Morley Michael P.; Rathi Komal S.; Wang Tao; Zhou Su; Cheng Lan; Lu Min Min; Morrisey Edward E.;
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作者单位

Univ Penn, Dept Med, Philadelphia, PA 19104 USA.;

Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.;

Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;

Univ Penn, Penn Inst Regenerat Med, Philadelphia, PA 19104 USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Hedgehog: the key to maintaining adult lung repair and regeneration [J] . Amruthansh Sriperumbudur, Mason Breitzig, Richard Lockey, Journal of Cell Communication and Signaling . 2017,第1期

机译：刺猬：保持成人肺修复和再生的关键
2. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. [J] . Shea KL, Xiang W, LaPorta VS, Cell stem cell . 2010,第2期

机译：Sprouty1调节再生过程中自我更新的成年肌肉干细胞池的可逆静止。
3. The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration [J] . Swarr Daniel T., Herriges Michael, Li Shanru, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2019,第11a12期

机译：长的非致rna falcor调节Foxa2表达，以保持肺上皮稳态并促进再生
4. The role of sonic hedgehog in adult neural progenitor cell proliferation in vitro and in vivo [C] . Lai, K., Kaspar, . 2002

机译：刺猬在体外和体内在成年神经祖细胞增殖中的作用
5. Hedgehog Signaling Regulates Friend of GATA to Maintain Hematopoietic Progenitor Cells in Drosophila melanogaster. [D] . Baldeosingh, Rajkumar. 2016

机译：刺猬信号调节GATA的朋友，以维护果蝇中的造血祖细胞。
6. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration [O] . Tien Peng, David B. Frank, Rachel S. Kadzik, -1

机译：刺猬积极维持成人肺部静止并调节修复和再生
7. Notch2 signaling regulates Id4 and cell cycle genes to maintain neural stem cell quiescence in the adult hippocampus [O] . Runrui Zhang, Marcelo Boareto, Anna Engler, 2018

机译：Notch2信号调节ID4和细胞周期基因，以保持成人海马的神经干细胞静脉曲张

Hedgehog actively maintains adult lung quiescence and regulates repairn and regeneration

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