Combinatorial gene regulation by modulation of relative pulse timing

Lin Yihan; Sohn Chang Ho; Dalal Chiraj K.; Cai Long; Elowitz Michael B.

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Combinatorial gene regulation by modulation of relative pulse timing

机译：通过调节相对脉冲时间来调节组合基因

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Studies of individual living cells have revealed that many transcription factors activate in dynamic, and often stochastic, pulses within the same cell. However, it has remained unclear whether cells might exploit the dynamic interaction of these pulses to control gene expression. Here, using quantitative single-cell time-lapse imaging of Saccharomyces cerevisiae, we show that the pulsatile transcription factors Msn2 and Mig1 combinatorially regulate their target genes through modulation of thei

机译：对单个活细胞的研究表明，许多转录因子在同一细胞内以动态脉冲（通常是随机脉冲）激活。然而，目前尚不清楚细胞是否可以利用这些脉冲的动态相互作用来控制基因表达。在这里，使用定量的酿酒酵母单细胞延时成像，我们显示了脉动转录因子Msn2和Mig1通过调制茶碱来联合调节其靶基因。

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《Nature》 |2015年第7576期|54-58|共5页
作者
Lin Yihan; Sohn Chang Ho; Dalal Chiraj K.; Cai Long; Elowitz Michael B.;
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CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA.;

CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.;

CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA.;

CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.;

CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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5. Algorithms for automatic generation of relative timing constraints . [D] . Xu, Yang. 2011

机译：自动生成相对时序约束的算法。
6. Combinatorial gene regulation by modulation of relative pulse timing [O] . Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, -1

机译：通过调节相对脉冲时间来调节组合基因
7. Combinatorial gene regulation by modulation of relative pulse timing [O] . Lin Yihan, Sohn Chang Ho, Dalal Chiraj K., 2015

机译：通过调节相对脉冲时间来调节组合基因

Combinatorial gene regulation by modulation of relative pulse timing

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