首页> 外文期刊>Nature >Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
【24h】

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV

机译:疫苗介导的SIV和HIV防护的免疫和病毒学机制

获取原文
获取原文并翻译 | 示例
           

摘要

A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; we identified a two-amino-acid signature that alters antigenicity and confers neutralization resistance. A similar signature confers resistance of human immunodeficiency virus (HIV)-1 to neutralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and HIV share a fundamental mechanism of immune escape from vaccine-elicited or naturally elicited antibodies. These analyses provide insight into the limited efficacy seen in HIV vaccine trials.
机译:开发高效艾滋病疫苗的主要挑战是确定保护性免疫机制。为了解决这个问题,我们使用了具有猿猴免疫缺陷病毒(SIV)的非人类灵长类动物攻击模型。我们表明,SIV包膜的抗体对于预防感染是必要和充分的。此外,对突破性感染病毒的测序显示出对中和敏感病毒的选择性压力。我们鉴定了一个可改变抗原性并赋予中和抗性的两个氨基酸的标记。相似的特征赋予人类免疫缺陷病毒(HIV)-1抵抗针对可变区1和2(V1V2)的单克隆抗体的抗性的能力,这表明SIV和HIV具有免疫逃避疫苗或自然引发抗体的基本机制。这些分析提供了对HIV疫苗试验中见效有限的见解。

著录项

  • 来源
    《Nature》 |2014年第7484期|502-508|共7页
  • 作者单位

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    SAIC-Frederick, Frederick National Laboratory, NIH, Frederick, Maryland 21702, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA,George Washington University, Washington DC 20052, USA;

    Los Alamos National Laboratories, Los Alamos, New Mexico 87545, USA;

    Department of Surgery, Duke University, Durham, North Carolina 27710, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA,Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA;

    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA;

    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA;

    Human Vaccine Institute, Duke University, Durham, North Carolina 27710, USA;

    Department of Surgery, Duke University, Durham, North Carolina 27710, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Fred Hutchison Cancer Research Center, Seattle, Washington 98109, USA;

    Biostatistics Research Branch, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Department of Surgery, Duke University, Durham, North Carolina 27710, USA;

    Human Vaccine Institute, Duke University, Durham, North Carolina 27710, USA;

    Human Vaccine Institute, Duke University, Durham, North Carolina 27710, USA;

    Department of Surgery, Duke University, Durham, North Carolina 27710, USA;

    Human Vaccine Institute, Duke University, Durham, North Carolina 27710, USA;

    Los Alamos National Laboratories, Los Alamos, New Mexico 87545, USA;

    Biostatistics Research Branch, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA,Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

    Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号