Poor diet boosts innate immunity

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Poor diet boosts innate immunity

机译：不良饮食会增强先天免疫力

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Vitamin A deficiency enhances the immune system's response to parasitic worm infections in mice. Malnutrition typically impairs the body's ability to fight infection. But Yasmine Belkaid at the US National Institutes of Health in Bethesda, Maryland, and her team found that depriving mice of vitamin A boosts an arm of the immune system that protects the body's barriers, such as the gut. Animals lacking this vitamin had a much higher level of ILC2 cells - immune cells that are active in barrier defence - in the gut than mice on a normal diet, and were better able to fend off infection by a nematode worm.

机译：维生素A缺乏症会增强免疫系统对小鼠寄生虫感染的反应。营养不良通常会损害人体抵抗感染的能力。但是马里兰州贝塞斯达市美国国家卫生研究院的Yasmine Belkaid和她的团队发现，剥夺小鼠维生素A可以增强免疫系统的手臂，从而保护人体的肠壁等屏障。缺乏这种维生素的动物比正常饮食的小鼠的肠道中具有更高水平的ILC2细胞（在屏障防御中活跃的免疫细胞）水平，并且能够更好地抵御线虫的感染。

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《Nature》 |2014年第7485期|589-589|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity [J] . Kowalczyk Aleksandra, Doener Fatma, Zanzinger Kai, Vaccine . 2016,第33期

机译：自佐剂mRNA疫苗诱导局部先天免疫反应，从而产生有效且可增强的适应性免疫
2. Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity [J] . Kowalczyk Aleksandra, Doener Fatma, Zanzinger Kai, Vaccine . 2016,第33期

机译：自佐剂mRNA疫苗诱导局部先天免疫反应，从而产生有效且可增强的适应性免疫
3. Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity. [J] . Schwartz M, London A, Shechter R Neuroscience: An International Journal under the Editorial Direction of IBRO . 2009,第3期

机译：增强T细胞免疫作为神经退行性疾病的治疗方法：先天免疫的作用。
4. A Temporal Analysis of the Bovine Innate Immune ResponseA Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Host Defense Peptides by Mass Spectrometry [C] . Jeffrey A. DeGrasse, Jamie L. Boehmer, Kevin J. Shefcheck, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：牛先天免疫应答牛先天性免疫应答的时间分析：质谱法鉴定和表征宿主防毒肽
5. Enhancing chicken innate immunity and disease resistance by boosting host defense peptide synthesis [D] . Sunkara, Lakshmi Tulasi. 2011

机译：通过增强宿主防御肽的合成来增强鸡的先天免疫力和疾病抵抗力
6. Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice [O] . Prashanta Silwal, Jin Kyung Kim, Sang Min Jeon, 2021

机译：Mitofusin-2通过维持有氧糖溶解和小鼠疾病激活来提高先天免疫力
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Poor diet boosts innate immunity

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