首页> 外文期刊>Nature >Vessels of rejuvenation
【24h】

Vessels of rejuvenation

机译:回春船

获取原文
获取原文并翻译 | 示例
           

摘要

The different structural and metabolic requirements of organs and tissues prompt the formation of specialized blood vessels during development, which deliver molecules that instruct tissues on their fates. This process requires crosstalk between organs and the vasculature: organs generate local growth factors that attract blood vessels toward metabolically active regions, and the vessels release molecules (known as angiocrine signals) that affect cell differentiation in the developing organs. It is becoming increasingly clear that these interactions are influenced by the endothelial cells that line the inner surface of blood vessels. In two papers in this issue, Adams and colleagues demonstrate that the bone vasculature contains specialized endothelial cells with signalling properties that support bone maturation and regeneration. As well as providing insight into the tissue specificity of angiocrine signalling, the findings have direct clinical relevance.
机译:器官和组织的不同结构和代谢要求会在发育过程中促使形成专门的血管,从而输送指示组织命运的分子。这个过程需要器官和脉管系统之间的串扰:器官产生局部生长因子,将血管吸引到代谢活跃区域,并且血管释放影响发育器官中细胞分化的分子(称为血管分泌信号)。越来越清楚的是,这些相互作用受到衬在血管内表面的内皮细胞的影响。在此问题的两篇论文中,Adams及其同事证明了骨脉管系统包含专门的内皮细胞,这些细胞具有支持骨成熟和再生的信号传导特性。除了提供对血管分泌信号的组织特异性的见识之外,这些发现还具有直接的临床意义。

著录项

  • 来源
    《Nature》 |2014年第7492期|313-314|共2页
  • 作者单位

    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany;

    Department of Intensive Care, VieCuri Medical Center, 5912 BL Venlo, the Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号