How best to build a cell

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How best to build a cell

机译：如何最好地建立一个细胞

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Synthetic biology is often described as bringing together engineers and biologists to build genetic circuits for some useful task. In fact, the field has engaged relatively few biologists. This is holding back its progress. We do not yet know enough biology to make synthetic biology a predictable engineering discipline. The engineering slant of synthetic biology has brought impressive accomplishments. These include whole-cell biosensors; cells that synthesize antimalaria drugs; and bacterial viruses designed to disperse dangerous, tenacious biofilms. To design these, engineers are trained to model systems as black boxes, abstractly linking inputs and outputs. They can often control a system with only a limited understanding of it. But synthetic-biology projects are frequently thwarted when engineering runs up against the complexity of biology.

机译：合成生物学通常被描述为将工程师和生物学家召集在一起，为一些有用的任务建立遗传回路。实际上，该领域的生物学家相对较少。这阻碍了它的进展。我们还没有足够的生物学知识来使合成生物学成为可预测的工程学科。合成生物学的工程学倾向带来了令人瞩目的成就。这些包括全细胞生物传感器；合成抗疟疾药物的细胞；以及旨在散布危险的顽强生物膜的细菌病毒。为了设计这些，工程师受过训练，将系统建模为黑匣子，抽象地将输入和输出链接起来。他们通常只能以有限的了解来控制系统。但是，当工程学遇到生物学的复杂性时，合成生物学项目通常会受到挫败。

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《Nature》 |2014年第7499期|155-157|共3页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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How best to build a cell

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