Mikala Egeblad was blown away when she made her first action film of tumour cells inside live mice. Until then, she had studied samples on microscope slides, where the cells sat still, frozen in time. But seeing them in a living animal brought the cells to life. "You turn on the microscope and look in the live mouse and suddenly these same cells are running around like crazy," says Egeblad, a cancer researcher at Cold Spring Harbor Laboratory in New York.
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