Track function in ageing animals

Douglas Seals; Simon Melov

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Track function in ageing animals

机译：追踪衰老动物的功能

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摘要

Much is known about how humans age. Over the past decades, ger-ontologists and geriatricians have developed batteries of tests to assess declines in physiological function as people age. For example, the ability of insulin to clear glucose from blood tracks the risk of diabetes; stiffer arteries indicate a future of hypertension and cognitive impairments, and reduced bone density increases risk of fracture.Rigorous studies have compared groups of young and older adults or followed the same individuals over time to establish many function-based markers of ageing. Indeed, life expectancy and the likelihood of disability for people over 65 years can be predicted from reductions in grip strength, average walking speed, or the ability to sit and rise from the floor.

机译：关于人类的年龄，人们已经知道了很多。在过去的几十年中，老年科医生和老年病学家开发了一系列测试来评估随着年龄的增长生理功能的下降。例如，胰岛素清除血液中葡萄糖的能力可追踪患糖尿病的风险；较僵硬的动脉预示着高血压和认知障碍的未来，并且骨密度降低会增加骨折的风险。严格的研究比较了成年和老年人组，或随着时间的推移追踪同一个人，以建立许多基于功能的衰老标记。实际上，可以通过降低握力，平均步行速度或从地板坐起和抬起的能力来预测65岁以上人群的预期寿命和残障可能性。

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来源
《Nature》 |2014年第7510期|406-407|共2页
作者
Douglas Seals; Simon Melov;
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作者单位

Department of Integrative Physiology at the University of Colorado Boulder in Boulder,Colorado, USA;

Buck Institute for Research on Aging in Novato, California, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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Track function in ageing animals

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