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Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons

机译：特定于方式的丘脑皮质输入指示突触后L4神经元的身份

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摘要

During development, thalamocortical (TC) input has a critical role in the spatial delineation and patterning of cortical areas, yet the underlying cellular and molecular mechanisms that drive cortical neuron differentiation are poorly understood. In the primary (S1) and secondary (S2) somatosensory cortex, layer 4 (L4) neurons receive mutually exclusive input originating from two thalamic nuclei: the ventrobasalis (VB), which conveys tactile input, and the posterior nucleus (Po), which conveys modulatory and nociceptive input. Recently, we have shown that L4 neuron identity is not fully committed postnatally, implying a capacity for TC input to influence differentiation during cortical circuit assembly. Here we investigate whether the cell-type-specific molecular and functional identity of L4 neurons is instructed by the origin of their TC input. Genetic ablation of the VB at birth resulted in an anatomical and functional rewiring of Po projections onto L4 neurons in S1. This induced acquisition of Po input led to a respecification of postsynaptic L4 neurons, which developed functional molecular features of Po-target neurons while repressing VB-target traits. Respecified L4 neurons were able to respond both to touch and to noxious stimuli, in sharp contrast to the normal segregation of these sensory modalities in distinct cortical circuits. These findings reveal a behaviourally relevant TC-input-type-specific control over the molecular and functional differentiation of postsynaptic L4 neurons and cognate intracortical circuits, which instructs the development of modality-specific neuronal and circuit properties during corticogenesis.
机译：在发育过程中，丘脑皮质（TC）输入在皮质区域的空间描绘和图案形成中起着至关重要的作用，但对皮质神经元分化的潜在细胞和分子机制了解甚少。在初级（S1）和次级（S2）的体感皮层中，第4层（L4）神经元接收来自两个丘脑核的互斥输入：传递触觉输入的腹基（VB）和后核（Po）。传达调节性和伤害性输入。最近，我们已经表明，L4神经元身份在出生后并未完全确定，这暗示了TC输入在皮质回路组装过程中影响分化的能力。在这里，我们调查L4神经元的细胞类型特异性分子和功能同一性是否由其TC输入的起源指示。出生时VB的遗传消融导致Po投射在S1的L4神经元上的解剖学和功能重新连接。这种诱导的Po输入的获取导致突触后L4神经元的重新指定，后者在抑制VB目标性状的同时发展了Po目标神经元的功能分子特征。特定的L4神经元能够对触摸和有害刺激做出反应，这与这些感觉方式在不同皮层回路中的正常分离形成鲜明对比。这些发现揭示了行为相关的TC输入类型特异性控制突触后L4神经元和相关皮质内回路的分子和功能分化，这指示了皮质形成过程中特定于形态的神经元和回路特性的发展。

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  • 来源
    《Nature》 |2014年第7510期|471-474|共4页
  • 作者

    Gabrielle Pouchelon; Frederic Gambino; Camilla Bellone; Ludovic Telley; Ilaria Vitali; Christian Luescher; Anthony Holtmaat; Denis Jabaudon;

  • 作者单位

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland,Interdisciplinary Institute for NeuroScience, CNRS UMP 5297, 33077 Bordeaux, France;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland,Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, CH-1211 Geneva, Switzerland,Institute of Genetics & Genomics in Geneva (iGE3), University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland;

    Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland,Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, CH-1211 Geneva, Switzerland,Institute of Genetics & Genomics in Geneva (iGE3), University of Geneva, CH-1211 Geneva, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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