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Relax and come in

机译：放松并进来

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摘要

淋巴结是动态结构,它们必须对由局部炎症引发的大量细胞涌入迅速做出反应。然而,淋巴结基质腔室是怎样反应来适应淋巴结膨胀的仍不清楚。这项研究显示,淋巴结基质腔室能通过放松成纤维网状细胞的细胞骨架、允许这些细胞伸展和淋巴结膨胀来容留大量渗透的淋巴细胞。这种淋巴结重塑反应是由进来的、能够呈现抗原的树状细胞上的CLEC-2蛋白与成纤维网状细胞上的"平足蛋白"(podoplanin)的相互作用驱动的。%Mechanical forces are key elements in the developmental control of organ size. Adjusting the size of lymph nodes is a special challenge, because immune cells continually enter and exit the organs from the bloodstream, and the number of cells the nodes contain can rapidly increase during an immune or inflammatory response. Despite these dramatic changes in cellularity, the structural backbone of lymph nodes - a network of stromal fibroblastic reticular cells - remains relatively stable. In this issue, Acton et al. (page 498) show that, during inflammation, immune cells called dendritic cells transmit a signal that triggers the physical relaxation of these stromal cells, thereby making space for more immune cells to enter the lymph nodes. This mechanical control aids rapid swelling of the organ, without substantial remodelling or proliferation of the stromal cells.
机译：淋巴结是动态结构,它们必须对由局部炎症引发的大量细胞涌入迅速做出反应。然而,淋巴结基质腔室是怎样反应来适应淋巴结膨胀的仍不清楚。这项研究显示,淋巴结基质腔室能通过放松成纤维网状细胞的细胞骨架、允许这些细胞伸展和淋巴结膨胀来容留大量渗透的淋巴细胞。这种淋巴结重塑反应是由进来的、能够呈现抗原的树状细胞上的CLEC-2蛋白与成纤维网状细胞上的"平足蛋白"(podoplanin)的相互作用驱动的。%Mechanical forces are key elements in the developmental control of organ size. Adjusting the size of lymph nodes is a special challenge, because immune cells continually enter and exit the organs from the bloodstream, and the number of cells the nodes contain can rapidly increase during an immune or inflammatory response. Despite these dramatic changes in cellularity, the structural backbone of lymph nodes - a network of stromal fibroblastic reticular cells - remains relatively stable. In this issue, Acton et al. (page 498) show that, during inflammation, immune cells called dendritic cells transmit a signal that triggers the physical relaxation of these stromal cells, thereby making space for more immune cells to enter the lymph nodes. This mechanical control aids rapid swelling of the organ, without substantial remodelling or proliferation of the stromal cells.

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  • 来源
    《Nature》 |2014年第7523期|441-442B2|共3页
  • 作者

    KARI VAAHTOMERI; MICHAEL SIXT;

  • 作者单位

    Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria;

    Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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