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首页> 外文期刊>Nature >A relative shift in cloacal location repositions external genitalia in amniote evolution
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A relative shift in cloacal location repositions external genitalia in amniote evolution

机译：泄殖腔位置的相对移位重新定位了羊膜进化过程中的外生殖器

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摘要

The move of vertebrates to a terrestrial lifestyle required major adaptations in their locomotory apparatus and reproductive organs. While the fin-to-limb transition has received considerable attention, little is known about the developmental and evolutionary origins of external genitalia. Similarities in gene expression have been interpreted as a potential evolutionary link between the limb and genitals; however, no underlying developmental mechanism has been identified. We re-examined this question using micro-computed tomography, lineage tracing in three amniote clades, and RNA-sequencing-based transcriptional profiling. Here we show that the developmental origin of external genitalia has shifted through evolution, and in some taxa limbs and genitals share a common primordium. In squamates, the genitalia develop directly from the budding hindlimbs, or the remnants thereof, whereas in mice the genital tubercle originates from the ventral and tail bud mesenchyme. The recruitment of different cell populations for genital outgrowth follows a change in the relative position of the cloaca, the genitalia organizing centre. Ectopic grafting of the cloaca demonstrates the conserved ability of different mesenchymal cells to respond to these genitalia-inducing signals. Our results support a limb-like developmental origin of external genitalia as the ancestral condition. Moreover, they suggest that a change in the relative position of the cloacal signalling centre during evolution has led to an altered developmental route for external genitalia in mammals, while preserving parts of the ancestral limb molecular circuitry owing to a common evolutionary origin.
机译：脊椎动物向陆生生活方式的转移需要对其运动器官和生殖器官进行重大适应。从鳍到肢的过渡受到了相当大的关注，但对外部生殖器的发育和进化起源知之甚少。基因表达的相似性已被解释为肢体与生殖器之间潜在的进化联系。但是，尚未发现潜在的发展机制。我们使用微计算机断层扫描，三个羊膜进化枝中的谱系追踪以及基于RNA测序的转录谱，重新检查了这个问题。在这里，我们显示外部生殖器的发育起源已通过进化转移，并且在某些分类单元中，肢体和生殖器具有共同的原基。在鳞状细胞中，生殖器直接从出芽的后肢或其残余物中发育，而在小鼠中，生殖器结节起源于腹侧和尾芽间充质。生殖器组织中心泄殖腔的相对位置发生变化后，便招募了不同的生殖器细胞群。泄殖腔的异位移植证明了不同间充质细胞对这些生殖器诱导信号作出反应的保守能力。我们的研究结果支持外生殖器的四肢状发育起源为祖先状态。此外，他们认为进化过程中泄殖腔信号中心相对位置的变化已导致哺乳动物外生殖器的发育途径发生了改变，同时由于共同的进化起源而保留了祖先肢体分子电路的一部分。

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  • 来源
    《Nature》 |2014年第7531期|391-394|共4页
  • 作者

    Patrick Tschopp; Emma Sherratt; Thomas J. Sanger; Anna C. Groner; Ariel C. Aspiras; Jimmy K. Hu; Olivier Pourquie; Jerome Gros; Clifford J. Tabin;

  • 作者单位

    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA;

    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA,Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, Iowa 50011, USA;

    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA,Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610, USA;

    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA;

    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA;

    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA,Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, UCSF, San Francisco, California 94143, USA;

    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA,Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), 67400 Illkirch, France,Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA;

    Developmental and Stem Cell Biology Department, Institut Pasteur, 75724 Paris Cedex 15, France;

    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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