Metabolism of inflammation limited by AMPK and pseudo-starvation

Luke A. J. ONeill; D. Grahame Hardie

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Metabolism of inflammation limited by AMPK and pseudo-starvation

机译：AMPK和假饥饿限制了炎症的代谢

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Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor la and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.

机译：参与炎症的细胞（例如活化的巨噬细胞和T-helper 17细胞）的代谢变化包括葡萄糖吸收增加，糖酵解和戊糖磷酸途径活性增加。已经提出了在针对缺氧诱导因子Ia和AMP激活的蛋白激酶的这些变化中相反的作用。相反，抗炎细胞，例如M2巨噬细胞，调节性T细胞和静态记忆T细胞，具有较低的糖酵解速率和较高的氧化代谢水平。某些抗炎药可能通过激活AMP激活的蛋白激酶来诱导类似于假饥饿的状态。因此，新陈代谢的改变可能参与了促进或抑制炎症的信号导向程序。

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《Nature》 |2013年第7432期|346-355|共10页
作者
Luke A. J. ONeill; D. Grahame Hardie;
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作者单位

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland;

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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机译：AMPK和假饥饿限制了炎症的代谢

Metabolism of inflammation limited by AMPK and pseudo-starvation

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